Prognostic Value of MRS Metabolites in Postoperative Irradiated High Grade Gliomas.

Autor: Tolia M; 2nd Department of Radiology, Radiation Oncology Unit, Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 12462 Athens, Greece., Verganelakis D; Encefalos Radiology Center, 3 Rizareiou & Chrisostomou Smirnis Street, Chalandri, 15233 Athens, Greece., Tsoukalas N; Medical Oncology Unit, 401 General Army Hospital, 10-12 Gennimata Street, Ampelokipi, 11524 Athens, Greece., Kyrgias G; School of Health Sciences, Faculty of Medicine, Department of Radiotherapy, University of Thessaly, Biopolis, 41110 Larissa, Greece., Papathanasiou M; 2nd Department of Radiology, Radiation Oncology Unit, Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 12462 Athens, Greece., Mosa E; 2nd Department of Radiology, Radiation Oncology Unit, Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 12462 Athens, Greece., Kokakis I; 1st Department of Radiology, Radiation Oncology Unit, Medical School, Aretaieion University Hospital, Vas Sofias 104 Avenue, 11521 Athens, Greece., Kouvaris JR; 1st Department of Radiology, Radiation Oncology Unit, Medical School, Aretaieion University Hospital, Vas Sofias 104 Avenue, 11521 Athens, Greece., Pissakas G; Radiotherapy Department, Alexandra Hospital, 11521 Athens, Greece., Pistevou-Gombaki K; Department of Radiation Oncology, AHEPA Hospital, Aristotle University of Thessaloniki, 1 Kyriakidi Street, 54636 Thessaloniki, Greece., Kelekis N; 2nd Department of Radiology, Radiation Oncology Unit, Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 12462 Athens, Greece., Kouloulias V; 2nd Department of Radiology, Radiation Oncology Unit, Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 12462 Athens, Greece.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2015; Vol. 2015, pp. 341042. Date of Electronic Publication: 2015 Aug 03.
DOI: 10.1155/2015/341042
Abstrakt: Purpose: We studied the prognostic significance of Magnetic Resonance Spectroscopy (MRS) in operated high grade gliomas.
Materials and Methods: Twelve patients were treated with radiotherapy and Temozolomide. The MRS data were taken four weeks after operation (before radiotherapy) and every six months after the completion of RT. The N-acetyl aspartate, choline, creatine, and myo-inositol parameters were quantified, analyzed, and correlated to recurrence-free survival (RFS).
Results: The median RFS was 26.06 months. RFS was significantly worse in elderly patients (P = 0.001) along with the higher choline/creatine ratios at either baseline (P = 0.003) or six months post Radiotherapy (P = 0.042). Median RFS was 23 months in high choline/creatine levels ≥ 2 at 6 months after radiotherapy and 11 months for those with < 2 choline/creatine levels. There was a significant correlation of maximum difference of choline/creatine ratio with RFS (rho = 0.64, P = 0.045).
Conclusion: Age and choline/creatine ratio are strong independent prognostic factors in high grade gliomas.
Databáze: MEDLINE
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