Fatigue in Patients With Advanced Terminal Cancer Correlates With Inflammation, Poor Quality of Life and Sleep, and Anxiety/Depression.
| Autor: | Rodrigues AR; Faculdade de Medicina do ABC, Santo André, Brazil., Trufelli DC; Faculdade de Medicina do ABC, Santo André, Brazil., Fonseca F; Faculdade de Medicina do ABC, Santo André, Brazil., de Paula LC; Faculdade de Medicina do ABC, Santo André, Brazil., Giglio AD; Faculdade de Medicina do ABC, Santo André, Brazil aurodelgiglio@gmail.com. |
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| Jazyk: | angličtina |
| Zdroj: | The American journal of hospice & palliative care [Am J Hosp Palliat Care] 2016 Dec; Vol. 33 (10), pp. 942-947. Date of Electronic Publication: 2015 Aug 30. |
| DOI: | 10.1177/1049909115603055 |
| Abstrakt: | Purpose: To assess which laboratory and clinical factors are associated with fatigue in patients with terminal cancer. Methods: We evaluated 51 patients with advanced incurable solid tumors using the Chalder Fatigue Questionnaire (CFQ) and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale for fatigue; the Pittsburgh Sleep Quality Index (PSQI-BR) for sleep quality; the Hospital Anxiety and Depression Scale (HADS) for anxiety and depression; the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire, Version 3.0 (QLQ C-30); and Functional Assessment of Cancer Therapy (FACT) for quality of life. We also analyzed several inflammatory markers and the modified Glasgow prognostic score (mGPS). Results: We observed severe fatigue in 19 (38%) patients (FACIT-F score >36). There was a significant correlation between fatigue as evaluated by the CFQ and quality of sleep and between the CFQ mental fatigue subscale scores and TNF-α level. When fatigue was evaluated using the FACIT-F scale, we observed a significant association between fatigue and anxiety/depression, quality of sleep, mGPS, and hemoglobin levels. Fatigue measured both with the CFQ and FACIT-F scale correlated with poor quality of life according to the EORTC QLQ C-30. Conclusion: In patients with advanced cancer, fatigue is a common symptom associated with the presence of inflammation, poor quality of sleep, depression/anxiety, and poor quality of life. (© The Author(s) 2015.) |
| Databáze: | MEDLINE |
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