Laser-wakefield accelerators as hard x-ray sources for 3D medical imaging of human bone.

Autor: Cole JM; The John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2BZ, UK., Wood JC; The John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2BZ, UK., Lopes NC; 1] The John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2BZ, UK [2] GoLP, Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade de Lisboa, 1049-001, Portugal., Poder K; The John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2BZ, UK., Abel RL; Department of Surgery and Cancer, MSk Laboratory, Charing Cross Hospital, Imperial College London, London W6 8RF, UK., Alatabi S; The John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2BZ, UK., Bryant JS; The John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2BZ, UK., Jin A; Department of Mechanical Engineering, City and Guilds Building, Imperial College London, London SW7 2AZ, UK., Kneip S; The John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2BZ, UK., Mecseki K; The John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2BZ, UK., Symes DR; Central Laser Facility, Rutherford Appleton Laboratory, Didcot OX11 0QX, UK., Mangles SP; The John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2BZ, UK., Najmudin Z; The John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2BZ, UK.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2015 Aug 18; Vol. 5, pp. 13244. Date of Electronic Publication: 2015 Aug 18.
DOI: 10.1038/srep13244
Abstrakt: A bright μm-sized source of hard synchrotron x-rays (critical energy Ecrit > 30 keV) based on the betatron oscillations of laser wakefield accelerated electrons has been developed. The potential of this source for medical imaging was demonstrated by performing micro-computed tomography of a human femoral trabecular bone sample, allowing full 3D reconstruction to a resolution below 50 μm. The use of a 1 cm long wakefield accelerator means that the length of the beamline (excluding the laser) is dominated by the x-ray imaging distances rather than the electron acceleration distances. The source possesses high peak brightness, which allows each image to be recorded with a single exposure and reduces the time required for a full tomographic scan. These properties make this an interesting laboratory source for many tomographic imaging applications.
Competing Interests: The authors declare no competing financial interests.
Databáze: MEDLINE
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