Measurement of preoperative lobar lung function with computed tomography ventilation imaging: progress towards rapid stratification of lung cancer lobectomy patients with abnormal lung function.

Autor:	Eslick EM; Radiation Physics Laboratory, Sydney Medical School - Central, University of Sydney, Sydney, NSW, Australia., Bailey DL; Sydney Medical School - Northern, University of Sydney, St Leonards, NSW, Australia Department of Nuclear Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia., Harris B; Sydney Medical School - Northern, University of Sydney, St Leonards, NSW, Australia Department of Sleep and Respiratory Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia., Kipritidis J; Radiation Physics Laboratory, Sydney Medical School - Central, University of Sydney, Sydney, NSW, Australia., Stevens M; Sydney Medical School - Northern, University of Sydney, St Leonards, NSW, Australia Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, NSW, Australia., Li BT; Sydney Medical School - Northern, University of Sydney, St Leonards, NSW, Australia Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, NSW, Australia., Bailey E; Department of Nuclear Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia., Gradinscak D; Department of Nuclear Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia., Pollock S; Radiation Physics Laboratory, Sydney Medical School - Central, University of Sydney, Sydney, NSW, Australia., Htun C; Department of Sleep and Respiratory Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia., Turner R; School of Public Health and Community Medicine, University of New South Wales, Kensington, NSW, Australia., Eade T; Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, NSW, Australia., Aslani A; Department of Nuclear Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia., Snowdon G; Department of Nuclear Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia., Keall PJ; Radiation Physics Laboratory, Sydney Medical School - Central, University of Sydney, Sydney, NSW, Australia paul.keall@sydney.edu.au.
Jazyk:	angličtina
Zdroj:	European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery [Eur J Cardiothorac Surg] 2016 Apr; Vol. 49 (4), pp. 1075-82. Date of Electronic Publication: 2015 Aug 06.
DOI:	10.1093/ejcts/ezv276
Abstrakt:	Objectives: In lung cancer preoperative evaluation, functional lung imaging is commonly used to assess lobar function. Computed tomography ventilation (CT-V) imaging is an emerging lung function imaging modality. We compared CT-V imaging assessment of lobar function and its prediction of postoperative lung function to that achieved by (i) positron emission tomography ventilation (PET-V) imaging and (ii) the standard anatomical segment counting (ASC) method. We hypothesized (i) that CT-V and PET-V have similar relative lobar function and (ii) that functional imaging and anatomic assessment (ASC) yield different predicted postoperative (ppo) lung function and therefore could change clinical management. Methods: In this proof-of-concept study, 11 patients were subjected to pulmonary function tests, CT-V and PET-V imaging. The Bland-Altman plot, Pearson's correlation and linear regression analysis were used to assess the agreement between the CT-V-, PET-V- and ASC-based quantification of lobar function and in the ppo lung function. Results: CT-V and PET-V imaging demonstrated strong correlations in quantifying relative lobar function (r = 0.96; P < 0.001). A Wilcoxon-signed rank test showed no significant difference in the lobar function estimates between the two imaging modalities (P = 0.83). The Bland-Altman plot also showed no significant differences. The correlation between ASC-based lobar function estimates with ventilation imaging was low, r < 0.45; however, the predictions of postoperative lung function correlated strongly between all three methods. Conclusions: The assessment of lobar function from CT-V imaging correlated strongly with PET-V imaging, but had low correlations with ASC. CT-V imaging may be a useful alternative method in preoperative evaluation for lung cancer patients. (© The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)
Databáze:	MEDLINE
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