Expression of ARs in triple negative breast cancer tumors: a potential prognostic factor?

Autor: Giannos A; Department of Obstetrics and Gynaecology, Alexandra General Hospital, Medical School, University of Athens, Athens, Greece., Filipits M; Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Zagouri F; Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria ; Department of Clinical Therapeutics, Alexandra General Hospital, Medical School, University of Athens, Athens, Greece., Brandstetter A; Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Tsigginou A; Department of Obstetrics and Gynaecology, Alexandra General Hospital, Medical School, University of Athens, Athens, Greece., Sotiropoulou M; Department of Pathology, Alexandra General Hospital, Athens, Greece., Papaspyrou I; Department of Pathology, Alexandra General Hospital, Athens, Greece., Sergentanis TN; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Athens, Greece., Psaltopoulou T; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Athens, Greece., Rodolakis A; Department of Obstetrics and Gynaecology, Alexandra General Hospital, Medical School, University of Athens, Athens, Greece., Antsaklis A; Department of Obstetrics and Gynaecology, Alexandra General Hospital, Medical School, University of Athens, Athens, Greece., Dimopoulos MA; Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Dimitrakakis C; Department of Obstetrics and Gynaecology, Alexandra General Hospital, Medical School, University of Athens, Athens, Greece.
Jazyk: angličtina
Zdroj: OncoTargets and therapy [Onco Targets Ther] 2015 Jul 23; Vol. 8, pp. 1843-7. Date of Electronic Publication: 2015 Jul 23 (Print Publication: 2015).
DOI: 10.2147/OTT.S78254
Abstrakt: Background/aim: In light of the controversial published literature, this study aims to examine the potential prognostic role of AR immunohistochemical expression in triple negative breast cancer (TNBC).
Patients and Methods: Ninety patients with TNBC were included in this study; the associations between AR expression (Allred score), clinicopathological variables (stage, grade, histological subtype, tumor size, nodal status, age at diagnosis, Ki67 expression, and p53 expression), and overall survival were evaluated.
Results: AR expression was not associated with stage, grade, histological subtype, tumor size, nodal status, age at diagnosis, Ki67 expression, and p53 expression. AR immunopositivity was not associated with overall survival either at the univariate or at the multivariate Cox regression analysis (multivariate hazard ratio =0.66, 95% confidence interval: 0.26-1.70, P=0.393).
Conclusion: AR expression does not seem to play a prognostic role in TNBC.
Databáze: MEDLINE
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