Vedolizumab: An integrin-receptor antagonist for treatment of Crohn's disease and ulcerative colitis.

Autor:	Hahn L; Lindsay Hahn, Pharm.D., BCPS, is Assistant Professor of Pharmacy Practice; Ashton Beggs, Pharm.D., BCACP, is Assistant Professor of Pharmacy Practice; Kristy Wahaib, Pharm.D., BCPS, is Assistant Professor of Pharmacy Practice; Leela Kodali, Pharm.D., BCACP, is Assistant Professor of Pharmacy Practice; and Vanessa Kirkwood is a Pharm.D. student, College of Pharmacy, Belmont University, Nashville, TN., Beggs A; Lindsay Hahn, Pharm.D., BCPS, is Assistant Professor of Pharmacy Practice; Ashton Beggs, Pharm.D., BCACP, is Assistant Professor of Pharmacy Practice; Kristy Wahaib, Pharm.D., BCPS, is Assistant Professor of Pharmacy Practice; Leela Kodali, Pharm.D., BCACP, is Assistant Professor of Pharmacy Practice; and Vanessa Kirkwood is a Pharm.D. student, College of Pharmacy, Belmont University, Nashville, TN., Wahaib K; Lindsay Hahn, Pharm.D., BCPS, is Assistant Professor of Pharmacy Practice; Ashton Beggs, Pharm.D., BCACP, is Assistant Professor of Pharmacy Practice; Kristy Wahaib, Pharm.D., BCPS, is Assistant Professor of Pharmacy Practice; Leela Kodali, Pharm.D., BCACP, is Assistant Professor of Pharmacy Practice; and Vanessa Kirkwood is a Pharm.D. student, College of Pharmacy, Belmont University, Nashville, TN., Kodali L; Lindsay Hahn, Pharm.D., BCPS, is Assistant Professor of Pharmacy Practice; Ashton Beggs, Pharm.D., BCACP, is Assistant Professor of Pharmacy Practice; Kristy Wahaib, Pharm.D., BCPS, is Assistant Professor of Pharmacy Practice; Leela Kodali, Pharm.D., BCACP, is Assistant Professor of Pharmacy Practice; and Vanessa Kirkwood is a Pharm.D. student, College of Pharmacy, Belmont University, Nashville, TN., Kirkwood V; Lindsay Hahn, Pharm.D., BCPS, is Assistant Professor of Pharmacy Practice; Ashton Beggs, Pharm.D., BCACP, is Assistant Professor of Pharmacy Practice; Kristy Wahaib, Pharm.D., BCPS, is Assistant Professor of Pharmacy Practice; Leela Kodali, Pharm.D., BCACP, is Assistant Professor of Pharmacy Practice; and Vanessa Kirkwood is a Pharm.D. student, College of Pharmacy, Belmont University, Nashville, TN.
Jazyk:	angličtina
Zdroj:	American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists [Am J Health Syst Pharm] 2015 Aug 01; Vol. 72 (15), pp. 1271-8.
DOI:	10.2146/ajhp140449
Abstrakt:	Purpose: The pharmacology, pharmacokinetics, safety, efficacy, and dosing recommendations of vedolizumab, an integrin-receptor antagonist for the treatment of Crohn's disease (CD) and ulcerative colitis (UC), are reviewed. Summary: Vedolizumab is an integrin-receptor antagonist for the treatment of CD and UC in adults with moderately to severely active disease who have had an inadequate response with, lost response to, or were intolerant to anti-tumor necrosis factor (TNF) agents or immunomodulators or had an inadequate response with, were intolerant to, or demonstrated dependence on corticosteroids. Phase III clinical trials have demonstrated efficacy in achieving remission as induction and maintenance therapy in CD and UC. Remission was also achieved at week 10 in patients with CD in whom previous treatment with anti-TNF agents had failed. Adverse effects of vedolizumab include nasopharyngitis, headache, arthralgia, nausea, pyrexia, upper respiratory tract infection, fatigue, cough, bronchitis, influenza, back pain, rash, pruritus, sinusitis, oropharyngeal pain, and pain in the extremities. To date, no cases of progressive multifocal leukoencephalopathy (PML) have been reported. The recommended dose of vedolizumab in adults with UC or CD is 300 mg administered via intravenous infusion at zero, two, and six weeks, followed by every eight weeks. The average wholesale unit price is $5782.80, but a patient assistance program is available. Conclusion: Vedolizumab is a new alternative for patients with moderate-to-severe UC or CD, as well as patients who have not responded to anti-TNF agents. The current safety profile and lack of reported PML make it a promising addition to the treatment of these conditions. (Copyright © 2015 by the American Society of Health-System Pharmacists, Inc. All rights reserved.)
Databáze:	MEDLINE
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