| Autor: |
Alarif WM; a Department of Marine Chemistry , Faculty of Marine Sciences, King Abdulaziz University , P.O. Box 80207, Jeddah 21589 , Saudi Arabia., Al-Footy KO; b Department of Chemistry , Faculty of Science, King Abdulaziz University , P.O. Box 80203, Jeddah 21589 , Saudi Arabia., Zubair MS; b Department of Chemistry , Faculty of Science, King Abdulaziz University , P.O. Box 80203, Jeddah 21589 , Saudi Arabia.; c Department of Pharmacy , Faculty of Science, Tadulako University , Kampus Bumi Tadulako Tondo, Palu 94118 , Indonesia., Halid Ph M; b Department of Chemistry , Faculty of Science, King Abdulaziz University , P.O. Box 80203, Jeddah 21589 , Saudi Arabia., Ghandourah MA; a Department of Marine Chemistry , Faculty of Marine Sciences, King Abdulaziz University , P.O. Box 80207, Jeddah 21589 , Saudi Arabia., Basaif SA; b Department of Chemistry , Faculty of Science, King Abdulaziz University , P.O. Box 80203, Jeddah 21589 , Saudi Arabia., Al-Lihaibi SS; a Department of Marine Chemistry , Faculty of Marine Sciences, King Abdulaziz University , P.O. Box 80207, Jeddah 21589 , Saudi Arabia., Ayyad SE; b Department of Chemistry , Faculty of Science, King Abdulaziz University , P.O. Box 80203, Jeddah 21589 , Saudi Arabia.; d Department of Chemistry , Faculty of Science, Damietta University , Damietta , Egypt., Badria FA; e Department of Pharmacognosy , Faculty of Pharmacy, Mansoura University , Mansoura 35516 , Egypt. |
| Abstrakt: |
A new eudesmane sesquiterpenoid, eudesma-4(15),7-diene-5,11-diol (1) along with the known trinor-sesquiterene, teuhetenone (2), and a seco-eudesmane sesquiterpene, chabrolidione B (3), have been isolated from the Red Sea red alga Laurencia obtusa. The chemical structures were elucidated on the basis of extensive spectroscopic analysis. The antifungal and cytotoxic activities of the isolated metabolites were tested against several fungi, yeast and human mammary carcinoma cell line (MCF-7). Compounds 1 and 3 showed a much better activity [minimum inhibitory concentration (MIC): 2.9 μM] than that of amphotericin B (MIC: 4.6 μM). Interestingly, compound 2, the least active antifungal compound, retained the high anticancer activity against MCF-7 (22 μM) in comparison with cisplatin (59 μM), which was determined by employing lactate dehydrogenase assay. Compounds 1-3 are recorded here for the first time from algal flora. The chemotaxonomic importance of the isolated metabolites was discussed. |
