Prenatal undernutrition and leukocyte telomere length in late adulthood: the Dutch famine birth cohort study.

Autor:	de Rooij SR; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, s.r.derooij@amc.uva.nl., van Pelt AM; Centre for Reproductive Medicine, Women's and Children's Hospital, and., Ozanne SE; University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Cambridge, United Kingdom;, Korver CM; Centre for Reproductive Medicine, Women's and Children's Hospital, and., van Daalen SK; Centre for Reproductive Medicine, Women's and Children's Hospital, and., Painter RC; Department of Obstetrics and Gynaecology, Academic Medical Centre at the University of Amsterdam, Amsterdam, Netherlands;, Schwab M; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany; and., Viegas MH; Life Length Inc., Madrid, Spain., Roseboom TJ; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Department of Obstetrics and Gynaecology, Academic Medical Centre at the University of Amsterdam, Amsterdam, Netherlands;
Jazyk:	angličtina
Zdroj:	The American journal of clinical nutrition [Am J Clin Nutr] 2015 Sep; Vol. 102 (3), pp. 655-60. Date of Electronic Publication: 2015 Jul 15.
DOI:	10.3945/ajcn.115.112326
Abstrakt:	Background: Energy restriction in prenatal life has detrimental effects on later life health and longevity. Studies in rats have shown that the shortening of telomeres in key tissues plays an important role in this association. Objective: The aim of the current study was to investigate leukocyte telomere length in relation to prenatal famine exposure. Design: The Dutch famine birth cohort consists of 2414 term singleton men and women who were born between 1943 and 1947 in Amsterdam around the time of the famine. At a mean age of 68 y, telomere length and the percentage of short telomeres was assessed in a subsample of 131 cohort members, of whom 45 were born before the famine (control), 41 were exposed to famine during early gestation, and 45 were conceived after the famine (control). Median telomere length was determined in peripheral blood leukocytes by a high-throughput quantitative fluorescent in situ hybridization-based technology. Results: Leukocyte telomere length and the percentage of short telomeres did not differ between those exposed to famine during early gestation and those unexposed during gestation. A lower socioeconomic status at birth, frequent consumption of alcohol (specifically consumption of spirits), a history of cancer, and a lower self-reported health status were significantly associated with shorter leukocyte telomere length (all P ≤ 0.03). Currently having a job was significantly associated with a smaller percentage of short telomeres (P = 0.04). Conclusion: The results of the current study suggest that prenatal exposure to famine is not associated with the shortening of telomeres in peripheral blood leukocytes at age 68 y. (© 2015 American Society for Nutrition.)
Databáze:	MEDLINE
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