Age of blood and adverse outcomes in a maternity population.

Autor: Patterson JA; Clinical and Population Perinatal Health, Kolling Institute, University of Sydney, Sydney., Irving DO; Research and Development, Australian Red Cross Blood Service, Melbourne., Isbister JP; Northern Clinical School, University of Sydney, Sydney, NSW, Australia., Morris JM; Clinical and Population Perinatal Health, Kolling Institute, University of Sydney, Sydney., Mayson E; Clinical and Population Perinatal Health, Kolling Institute, University of Sydney, Sydney., Roberts CL; Clinical and Population Perinatal Health, Kolling Institute, University of Sydney, Sydney., Ford JB; Clinical and Population Perinatal Health, Kolling Institute, University of Sydney, Sydney.
Jazyk: angličtina
Zdroj: Transfusion [Transfusion] 2015 Nov; Vol. 55 (11), pp. 2730-7. Date of Electronic Publication: 2015 Jul 15.
DOI: 10.1111/trf.13230
Abstrakt: Background: In recent times there has been debate around whether longer storage time of blood is associated with increased rates of adverse outcomes after transfusion. It is unclear whether results focused on cardiac or critically ill patients apply to a maternity population. This study investigates whether older blood is associated with increased morbidity and readmission in women undergoing obstetric transfusion.
Study Design and Methods: Women giving birth in hospitals in New South Wales, Australia, between July 2006 and December 2010 were included in the study population if they had received between 1 and 4 red blood cell units during the birth admission. Information on women's characteristics, transfusions, and outcomes were obtained from five routinely collected data sets including blood collection, birth, and hospitalization data. Generalized propensity score methods were used to determine the effect of age of blood on rates of severe morbidity and readmission, independent of confounding factors.
Results: Transfusion data were available for 2990 women, with a median age of blood transfused of 20 days (interquartile range, 14-27 days). There were no differences in the maximum age of blood transfused between women with and without severe morbidity (21 [14-28] days vs. 22 [15-30] days) and in women readmitted or not (22 [14-28] days vs. 22 [16-30] days). After potential confounding factors were considered, no relationship was found between the age of blood transfused and rates of severe morbidity and readmission.
Conclusion: Among women receiving low-volume transfusions during a birth admission, there was no evidence of increased rates of adverse outcomes after transfusion with older blood.
(© 2015 AABB.)
Databáze: MEDLINE
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