Role of Autophagy in the Maintenance of Intestinal Homeostasis.

Autor:	Baxt LA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts., Xavier RJ; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: xavier@molbio.mgh.harvard.edu.
Jazyk:	angličtina
Zdroj:	Gastroenterology [Gastroenterology] 2015 Sep; Vol. 149 (3), pp. 553-62. Date of Electronic Publication: 2015 Jul 11.
DOI:	10.1053/j.gastro.2015.06.046
Abstrakt:	Genome-wide association studies of inflammatory bowel disease have identified several risk loci in genes that regulate autophagy, and studies have provided insight into the functional effects of these polymorphisms. We review the mechanisms by which autophagy contributes to intestinal homeostasis, focusing on its cell type-specific roles in regulating gut ecology, restricting pathogenic bacteria, and controlling inflammation. Based on this information, we are beginning to understand how alterations in autophagy can contribute to intestinal inflammation. (Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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