Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012).

Autor: Collette SA; Veterinary Medical Teaching Hospital, University of California-Davis, Davis, CA, USA.; Oncology Service, Upstate Veterinary Specialists, Greenville, SC, USA., Allstadt SD; Department of Surgical and Radiological Sciences, University of California-Davis, Davis, CA, USA.; Oncology Service, Blue Pearl Veterinary Partners, Louisville, KY, USA., Chon EM; Department of Medical Sciences, Univeristy of Wisconsin-Madison, Madison, WI, USA., Vernau W; Department of Pathology, Microbiology and Immunology, University of California-Davis, CA, USA., Smith AN; Department of Clinical Sciences, Auburn University, Auburn, AL, USA., Garrett LD; Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL, USA., Choy K; Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA, USA.; Oncology Service, Seattle Veterinary Specialists, Seattle, WA, USA., Rebhun RB; Department of Surgical and Radiological Sciences, University of California-Davis, Davis, CA, USA., Rodriguez CO Jr; Department of Surgical and Radiological Sciences, University of California-Davis, Davis, CA, USA., Skorupski KA; Department of Surgical and Radiological Sciences, University of California-Davis, Davis, CA, USA.
Jazyk: angličtina
Zdroj: Veterinary and comparative oncology [Vet Comp Oncol] 2016 Aug; Vol. 14 Suppl 1, pp. 136-46. Date of Electronic Publication: 2015 Jun 25.
DOI: 10.1111/vco.12158
Abstrakt: CHOP-based (cyclophosphamide, doxorubicin, vinca alkaloid, prednisolone) chemotherapy protocols are often recommended for treatment of feline lymphoma. While maintenance-free CHOP-based protocols have been published and readily used in dogs, there is limited literature regarding similar maintenance-free protocols in cats. The purpose of this study was to describe the outcome of cats with intermediate- to high-grade lymphoma that were prescribed a modified 25-week University of Wisconsin-Madison (UW-25) chemotherapy protocol. A secondary objective was examination of potential prognostic factors. One hundred and nineteen cats from five institutions treated with a UW-25-based protocol were included. The Kaplan-Meier median progression-free interval (PFI) and survival time (MST) were 56 and 97 (range 2-2019) days, respectively. Cats assessed as having a complete response (CR) to therapy had significantly longer PFI and MST than those with partial or no response (PFI 205 versus 54 versus 21 days, respectively, P < 0.0001 and MST 318 versus 85 versus 27 days, respectively, P < 0.0001).
Competing Interests: None of the authors of this paper have financial or personal relationship with other people or organizations that could inappropriately influence or bias the content of this paper.
(© 2015 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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