Severity of spinal cord injury influences diffusion tensor imaging of the brain.

Autor: Jirjis MB; Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin, USA., Vedantam A; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Budde MD; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Kalinosky B; Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin, USA., Kurpad SN; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Schmit BD; Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin, USA.
Jazyk: angličtina
Zdroj: Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2016 Jan; Vol. 43 (1), pp. 63-74. Date of Electronic Publication: 2015 Jun 10.
DOI: 10.1002/jmri.24964
Abstrakt: Background: The purpose of this study was to determine whether DTI changes in the brain induced by a thoracic spinal cord injury are sensitive to varying severity of spinal contusion in rats.
Methods: A control, mild, moderate, or severe contusion injury was administered over the eighth thoracic vertebral level in 32 Sprague-Dawley rats. At 11 weeks postinjury, ex vivo DTI of the brain was performed on a 9.4T Bruker scanner using a pulsed gradient spin-echo sequence.
Results: Mean water diffusion in the internal capsule regions of the brain and pyramid locations of the brainstem were correlated with motor function (r(2)  = 0.55). Additionally, there were significant differences between injury severity groups for mean diffusivity and fractional anisotropy at regions associated with the corticospinal tract (P = 0.05).
Conclusion: These results indicate that DTI is sensitive to changes in brain tissue as a consequence of thoracic SCI.
(© 2015 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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