Phylodynamics of Enterovirus A71-Associated Hand, Foot, and Mouth Disease in Viet Nam.

Autor:	Geoghegan JL; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia jemma.geoghegan@sydney.edu.au tanlv@oucru.org., Tan le V; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam jemma.geoghegan@sydney.edu.au tanlv@oucru.org., Kühnert D; Department of Environmental Systems Science, ETH Zurich, Zurich, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland., Halpin RA; J. Craig Venter Institute, Rockville, Maryland, USA., Lin X; J. Craig Venter Institute, Rockville, Maryland, USA., Simenauer A; J. Craig Venter Institute, Rockville, Maryland, USA., Akopov A; J. Craig Venter Institute, Rockville, Maryland, USA., Das SR; J. Craig Venter Institute, Rockville, Maryland, USA., Stockwell TB; J. Craig Venter Institute, Rockville, Maryland, USA., Shrivastava S; J. Craig Venter Institute, Rockville, Maryland, USA., Ngoc NM; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Uyen le TT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Tuyen NT; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Thanh TT; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Hang VT; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Qui PT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Hung NT; Children's Hospital 1, Ho Chi Minh City, Vietnam., Khanh TH; Children's Hospital 1, Ho Chi Minh City, Vietnam., Thinh le Q; Children's Hospital 1, Ho Chi Minh City, Vietnam., Nhan le NT; Children's Hospital 1, Ho Chi Minh City, Vietnam., Van HM; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Viet do C; Children's Hospital 2, Ho Chi Minh City, Vietnam., Tuan HM; Children's Hospital 2, Ho Chi Minh City, Vietnam., Viet HL; Children's Hospital 2, Ho Chi Minh City, Vietnam., Hien TT; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Chau NV; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Thwaites G; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Grenfell BT; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA., Stadler T; Swiss Institute of Bioinformatics, Lausanne, Switzerland Department of Biosystems Science and Engineering, ETH Zurich, Zurich, Switzerland., Wentworth DE; Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Holmes EC; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia., Van Doorn HR; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Jazyk:	angličtina
Zdroj:	Journal of virology [J Virol] 2015 Sep; Vol. 89 (17), pp. 8871-9. Date of Electronic Publication: 2015 Jun 17.
DOI:	10.1128/JVI.00706-15
Abstrakt:	Unlabelled: Enterovirus A71 (EV-A71) is a major cause of hand, foot, and mouth disease (HFMD) and is particularly prevalent in parts of Southeast Asia, affecting thousands of children and infants each year. Revealing the evolutionary and epidemiological dynamics of EV-A71 through time and space is central to understanding its outbreak potential. We generated the full genome sequences of 200 EV-A71 strains sampled from various locations in Viet Nam between 2011 and 2013 and used these sequence data to determine the evolutionary history and phylodynamics of EV-A71 in Viet Nam, providing estimates of the effective reproduction number (Re) of the infection through time. In addition, we described the phylogeography of EV-A71 throughout Southeast Asia, documenting patterns of viral gene flow. Accordingly, our analysis reveals that a rapid genogroup switch from C4 to B5 likely took place during 2012 in Viet Nam. We show that the Re of subgenogroup C4 decreased during the time frame of sampling, whereas that of B5 increased and remained >1 at the end of 2013, corresponding to a rise in B5 prevalence. Our study reveals that the subgenogroup B5 virus that emerged into Viet Nam is closely related to variants that were responsible for large epidemics in Malaysia and Taiwan and therefore extends our knowledge regarding its associated area of endemicity. Subgenogroup B5 evidently has the potential to cause more widespread outbreaks across Southeast Asia. Importance: EV-A71 is one of many viruses that cause HFMD, a common syndrome that largely affects infants and children. HFMD usually causes only mild illness with no long-term consequences. Occasionally, however, severe infection may arise, especially in very young children, causing neurological complications and even death. EV-A71 is highly contagious and is associated with the most severe HFMD cases, with large and frequent epidemics of the virus recorded worldwide. Although major advances have been made in the development of a potential EV-A71 vaccine, there is no current prevention and little is known about the patterns and dynamics of EV-A71 spread. In this study, we utilize full-length genome sequence data obtained from HFMD patients in Viet Nam, a geographical region where the disease has been endemic since 2003, to characterize the phylodynamics of this important emerging virus. (Copyright © 2015 Geoghegan et al.)
Databáze:	MEDLINE
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