[Decreased expression of calcium-sensing receptor involved in the progression of diabetic cardiomyopathy].
| Autor: | Jia Z, Sun J, Li HZ, Li HX, Peng X, Shao HJ, Yang JX, Xu CQ, Bai SZ |
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| Jazyk: | čínština |
| Zdroj: | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology [Zhongguo Ying Yong Sheng Li Xue Za Zhi] 2015 Jan; Vol. 31 (1), pp. 35-7. |
| Abstrakt: | Objective: To observe the dynamic expression of calcium-sensing receptor(CaSR) in myocardium of diabetic rats. Methods: Thirty male Wistar rats were randomly divided into 3 groups including control, diabetic-4 week and diabetic-8 week groups(n = 10). The type 2 diabetes mellitus models were established by intraperitoneal injection of streptozotocin (STZ, 30 mg/kg) after high-fat and high-sugar diet for one month. The cardiac morphology was observed by electron microscope. Western blot analyzed the expression of CaSR, phospholamban (PLN), a calcium handling regulator, and Ca+-ATPase(SERCA) in cardiac tissues. Results: Compared with control group, the expressions of CaSR and SERCA were decreased, while the expression of PLN was significantly increased in a time-dependent manner in diabetic groups. Meanwhile diabetic rats displayed abnormal cardiac structure. Conclusion: These results indicate that the CaSR expression of myocardium is reduced in the progression of DCM, and its potential mechanism may be related to the imnaired intracellular calcium homeostasis. |
| Databáze: | MEDLINE |
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