Emergence and potential for spread of Chikungunya virus in Brazil.

Autor: Nunes MR; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. marcionunesbrasil@yahoo.com.br., Faria NR; Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK. nuno.faria@zoo.ox.ac.uk., de Vasconcelos JM; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. janaina.mvasconcelos@yahoo.com.br., Golding N; Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK. nick.golding@zoo.ox.ac.uk., Kraemer MU; Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK. moritz.kraemer@zoo.ox.ac.uk., de Oliveira LF; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. layannafoliveira@gmail.com., Azevedo Rdo S; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. raimundaazevedo@iec.pa.gov.br., da Silva DE; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. daisydasilva@gmail.com., da Silva EV; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. elianapinto@iec.pa.gov.br., da Silva SP; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. spatroca@gmail.com., Carvalho VL; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. valeriacarvalho@iec.pa.gov.br., Coelho GE; National Dengue Control Program, Brazilian Ministry of Health, Brasilia, DF, 70058-900, Brazil. giovanini.coelho@saude.gov.br., Cruz AC; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. anacecilia@iec.pa.gov.br., Rodrigues SG; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. suelirodrigues@iec.pa.gov.br., Vianez JL Jr; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. joao.vianezjr@gmail.com., Nunes BT; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. brunonunes@iec.pa.gov.br., Cardoso JF; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. jedson.cardoso@iec.pa.gov.br., Tesh RB; Department of Pathology, University of Texas Medical Branch, Galveston, Texas TX, 77555-0609, USA. rtesh@utmb.edu., Hay SI; Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK. simon.i.hay@gmail.com.; Fogarty International Center, National Institutes of Health, Bethesda, MD, 20892, USA. simon.i.hay@gmail.com., Pybus OG; Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK. oliver.pybus@zoo.ox.ac.uk., Vasconcelos PF; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. pedro.vasconcelos@globo.com.; Department of Pathology, Para State University, Belem, PA, 66087-670, Brazil. pedro.vasconcelos@globo.com.
Jazyk: angličtina
Zdroj: BMC medicine [BMC Med] 2015 Apr 30; Vol. 13, pp. 102. Date of Electronic Publication: 2015 Apr 30.
DOI: 10.1186/s12916-015-0348-x
Abstrakt: Background: In December 2013, an outbreak of Chikungunya virus (CHIKV) caused by the Asian genotype was notified in the Caribbean. The outbreak has since spread to 38 regions in the Americas. By September 2014, the first autochthonous CHIKV infections were confirmed in Oiapoque, North Brazil, and in Feira de Santana, Northeast Brazil.
Methods: We compiled epidemiological and clinical data on suspected CHIKV cases in Brazil and polymerase-chain-reaction-based diagnostic was conducted on 68 serum samples from patients with symptom onset between April and September 2014. Two imported and four autochthonous cases were selected for virus propagation, RNA isolation, full-length genome sequencing, and phylogenetic analysis. We then followed CDC/PAHO guidelines to estimate the risk of establishment of CHIKV in Brazilian municipalities.
Results: We detected 41 CHIKV importations and 27 autochthonous cases in Brazil. Epidemiological and phylogenetic analyses indicated local transmission of the Asian CHIKV genotype in Oiapoque. Unexpectedly, we also discovered that the ECSA genotype is circulating in Feira de Santana. The presumed index case of the ECSA genotype was an individual who had recently returned from Angola and developed symptoms in Feira de Santana. We estimate that, if CHIKV becomes established in Brazil, transmission could occur in 94% of municipalities in the country and provide maps of the risk of importation of each strain of CHIKV in Brazil.
Conclusions: The etiological strains associated with the early-phase CHIKV outbreaks in Brazil belong to the Asian and ECSA genotypes. Continued surveillance and vector mitigation strategies are needed to reduce the future public health impact of CHIKV in the Americas.
Databáze: MEDLINE
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