The role of piRNA and its potential clinical implications in cancer.

Autor: Assumpção CB; Laboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Rua Augusto Corrêa, 01, Guamá, CEP: 66075-110, Belém-PA, Brazil., Calcagno DQ; Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Av. Mundurucus, 4487, Guamá, CEP: 66073-000, Belém-PA, Brazil., Araújo TM; Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Av. Mundurucus, 4487, Guamá, CEP: 66073-000, Belém-PA, Brazil., Santos SE; Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Av. Mundurucus, 4487, Guamá, CEP: 66073-000, Belém-PA, Brazil., Santos ÂK; Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Av. Mundurucus, 4487, Guamá, CEP: 66073-000, Belém-PA, Brazil., Riggins GJ; Department of Neurosurgery, School of Medicine, Johns Hopkins University, 1550 Orleans Street, Room 257 CRB2, Baltimore, MD 21231, USA., Burbano RR; Laboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Rua Augusto Corrêa, 01, Guamá, CEP: 66075-110, Belém-PA, Brazil., Assumpção PP; Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Av. Mundurucus, 4487, Guamá, CEP: 66073-000, Belém-PA, Brazil.
Jazyk: angličtina
Zdroj: Epigenomics [Epigenomics] 2015; Vol. 7 (6), pp. 975-84. Date of Electronic Publication: 2015 May 01.
DOI: 10.2217/epi.15.37
Abstrakt: Epigenetic mechanisms work in an orchestrated fashion to control gene expression in both homeostasis and diseases. Among small noncoding RNAs, piRNAs seem to meet the necessary requirements to be included in this epigenetic network due to their role in both transcriptional and post-transcriptional regulation. piRNAs and PIWI proteins might play important roles in cancer occurrence, prognosis and treatment as reported previously. Nevertheless, the potential clinical relevance of these molecules has yet been elucidated. A brief overview of piRNA biogenesis and their potential roles as part of an epigenetic network that is possibly involved in cancer is provided. Moreover, potential strategies based on the use of piRNAs and PIWI proteins as diagnostic and prognostic biomarkers as well as for cancer therapeutics are discussed.
Databáze: MEDLINE