Efficacy and safety of creatine supplementation in juvenile dermatomyositis: A randomized, double-blind, placebo-controlled crossover trial.

Autor: Solis MY; School of Medicine, University of São Paulo, Sao Paulo, Brazil., Hayashi AP; School of Medicine, University of São Paulo, Sao Paulo, Brazil., Artioli GG; School of Physical Education and Sport, University of São Paulo, Sao Paulo, Brazil., Roschel H; School of Physical Education and Sport, University of São Paulo, Sao Paulo, Brazil., Sapienza MT; School of Medicine, University of São Paulo, Sao Paulo, Brazil., Otaduy MC; School of Medicine, University of São Paulo, Sao Paulo, Brazil., De Sã Pinto AL; School of Medicine, University of São Paulo, Sao Paulo, Brazil., Silva CA; School of Medicine, University of São Paulo, Sao Paulo, Brazil., Sallum AM; School of Medicine, University of São Paulo, Sao Paulo, Brazil., Pereira RM; School of Medicine, University of São Paulo, Sao Paulo, Brazil., Gualano B; School of Physical Education and Sport, University of São Paulo, Sao Paulo, Brazil.
Jazyk: angličtina
Zdroj: Muscle & nerve [Muscle Nerve] 2016 Jan; Vol. 53 (1), pp. 58-66. Date of Electronic Publication: 2015 Nov 23.
DOI: 10.1002/mus.24681
Abstrakt: Introduction: It has been suggested that creatine supplementation is safe and effective for treating idiopathic inflammatory myopathies, but no pediatric study has been conducted to date. The objective of this study was to examine the efficacy and safety of creatine supplementation in juvenile dermatomyositis (JDM) patients.
Methods: In this study, JDM patients received placebo or creatine supplementation (0.1 g/kg/day) in a randomized, crossover, double-blind design. Subjects were assessed at baseline and after 12 weeks. The primary outcome was muscle function. Secondary outcomes included body composition, aerobic conditioning, health-related quality of life, and muscle phosphocreatine (PCr) content. Safety was assessed by laboratory parameters and kidney function measurements.
Results: Creatine supplementation did not affect muscle function, intramuscular PCr content, or any other secondary outcome. Kidney function was not affected, and no side effects were reported.
Conclusions: Twelve weeks of creatine supplementation in JDM patients were well-tolerated and free of adverse effects, but treatment did not affect muscle function, intramuscular PCr, or any other parameter.
(© 2015 Wiley Periodicals, Inc.)
Databáze: MEDLINE
Externí odkaz: