The efficacy and nephrotoxicity associated with colistin use in an intensive care unit in Vietnam: Use of colistin in a population of lower body weight.

Autor:	Binh NG; Intensive Care Unit of Bach Mai Hospital, Hanoi, Vietnam., Hayakawa K; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan. Electronic address: kayokohayakawa@gmail.com., Co DX; Intensive Care Unit of Bach Mai Hospital, Hanoi, Vietnam., Tuan ND; Intensive Care Unit of Bach Mai Hospital, Hanoi, Vietnam., Anh NH; Hanoi University of Pharmacy, Hanoi, Vietnam., Thuy NT; Pharmacy department of Bach Mai Hospital, Hanoi, Vietnam., Phuong DM; Microbiology Department of Bach Mai hospital, Hanoi, Vietnam., Huong NT; Hanoi University of Pharmacy, Hanoi, Vietnam., Thuy PT; National Center for Global Health and Medicine - Bach Mai hospital Medical Collaboration Center., Chau NQ; Respiratory Department, Bach Mai Hospital, Hanoi, Vietnam., Nhung PH; Microbiology Department of Bach Mai hospital, Hanoi, Vietnam., Gam do TH; Pharmacy department of Bach Mai Hospital, Hanoi, Vietnam., Hai DT; Pharmacy department of Bach Mai Hospital, Hanoi, Vietnam., Huong TT; Pharmacy department of Bach Mai Hospital, Hanoi, Vietnam., Van Anh L; Pharmacy department of Bach Mai Hospital, Hanoi, Vietnam., Takeshita N; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan., Ohmagari N; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2015 Jun; Vol. 35, pp. 18-23. Date of Electronic Publication: 2015 Mar 30.
DOI:	10.1016/j.ijid.2015.03.020
Abstrakt:	Background: There has been a growing need for colistin as a key drug for the treatment of MDR-GNB infection. Information on colistin use in Asian population is limited. Methods: A retrospective observational study was conducted to assess the efficacy and nephrotoxicity in critically ill adult patients who received intravenous colistin for MDR-GNB infection in the intensive care unit (ICU) at Bach Mai Hospital in Hanoi, Vietnam. Colistin was administered according to the dosing guideline that was based on pharmacokinetic, pharmacodynamic and toxicodynamic principles, adjusted by body weight and creatinine clearance. Results: Twenty-eight eligible patients were included. The mean patient age was 60±20.4 years. The mean body weight was 53±8.6kg. The mean daily dose of colistin was 4.1±1.6 MIU, and the mean cumulative dose of colistin was 48.2±22.8 MIU. Colistin therapies were classified as clinically effective in 19 (67.9%) cases. Six (21.4%) patients developed nephrotoxicity during the study period according to RIFLE criteria. Conclusion: A personalized dosing protocol of colistin was effective, with low nephrotoxicity, among critically ill Vietnamese patients with low body weight. Further studies are warranted for assessing the efficacy and toxicity in a larger cohort. (Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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