Intraventricular granulomatous mass associated with Mycobacterium haemophilum: A rare central nervous system manifestation in a patient with human immunodeficiency virus infection.

Autor: Barr LK; Department of Neurological Surgery, Rutgers New Jersey Medical School, Suite 8100, 90 Bergen Street, Newark, NJ 07103, USA., Sharer LR; Department of Pathology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA., Khadka Kunwar E; Division of Infectious Diseases, Rutgers New Jersey Medical School, Newark, NJ, USA., Kapila R; Division of Infectious Diseases, Rutgers New Jersey Medical School, Newark, NJ, USA., Zaki SR; Centers for Disease Control and Prevention, Infectious Diseases Pathology Branch, Atlanta, GA, USA., Drew CP; Centers for Disease Control and Prevention, Infectious Diseases Pathology Branch, Atlanta, GA, USA., Bhatnagar J; Centers for Disease Control and Prevention, Infectious Diseases Pathology Branch, Atlanta, GA, USA., Liu JK; Department of Neurological Surgery, Rutgers New Jersey Medical School, Suite 8100, 90 Bergen Street, Newark, NJ 07103, USA. Electronic address: james.liu.md@rutgers.edu., Chew D; Division of Infectious Diseases, Rutgers New Jersey Medical School, Newark, NJ, USA.
Jazyk: angličtina
Zdroj: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2015 Jun; Vol. 22 (6), pp. 1057-60. Date of Electronic Publication: 2015 Mar 25.
DOI: 10.1016/j.jocn.2014.11.036
Abstrakt: We report a rare case of Mycobacterium haemophilum presenting as an intraventricular granulomatous mass with loculated hydrocephalus and seizures in a patient with human immunodeficiency virus. M. haemophilum, a slow-growing mycobacteria, causes localized and disseminated disease among immunocompromised hosts. Central nervous system infection with M. haemophilum is extremely rare. Preoperative laboratory testing of our patient for tuberculosis, toxoplasmosis, sarcoidosis and histoplasmosis were negative. Surgical resection of the mass revealed a caseating granuloma that stained positive for acid-fast bacillus suggesting possible tuberculoma. Despite negative testing for tuberculosis, a polymerase chain reaction analysis was ultimately performed from the resected mass which revealed M. haemophilum. To our knowledge, this is the first case of M. haemophilum presenting as an intraventricular mass. We review the clinical manifestations of this pathogen and discuss the medical and surgical management.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: