Use of ERC-1671 Vaccine in a Patient with Recurrent Glioblastoma Multiforme after Progression during Bevacizumab Therapy: First Published Report.

Autor: Bota DA; Associate Professor of Neurology and Neurosurgery at the University of California, Irvine in the City of Orange. dbota@uci.edu., Alexandru-Abrams D; Neurosurgery Resident at the University of California, Irvine Medical Center in the City of Orange. danielaa@uci.edu., Pretto C; Laboratory Manager for Epitopoietic Research Corporation at the Scientific Park Crealys in Gemblous, Les Ines, Belgium. pretto@ercbelgium.eu., Hofman FM; Professor of Pathology at the Keck School of Medicine, University of Southern California, Los Angeles. hofman@usc.edu., Chen TC; Chief Medical Officer of Epitopoietic Research Corporation and a Professor of Neurosurgery at the Keck School of Medicine, University of Southern California, Los Angeles. tcchen@usc.edu., Fu B; Neurological Oncology Nurse Practitioner in the Neurology Department of the University of California, Irvine Medical Center in the City of Orange. dfu@uci.edu., Carrillo JA; Assistant Professor of Neurology at the University of California, Irvine Medical Center in the City of Orange. carrilj2@uci.edu., Schijns VE; Chief Security Officer of Epitopoietic Research Corporation and a Professor of Immune Intervention in the Department of Cell Biology and Immunology at the Wageningen University in Netherlands. virgil.schijns@wur.nl., Stathopoulos A; Chief Executive Officer for Epitopoietic Research Corporation at the Scientific Park Crealys in Gemblous, Les Ines, Belgium and Chief Neurosurgeon, Department of Neurosurgery, Arlon Hospital, Belgium. tstath@hotmail.com.
Jazyk: angličtina
Zdroj: The Permanente journal [Perm J] 2015 Spring; Vol. 19 (2), pp. 41-6. Date of Electronic Publication: 2015 Mar 01.
DOI: 10.7812/TPP/14-042
Abstrakt: Glioblastoma multiforme is a highy aggressive tumor that recurs despite resection, focal beam radiation, and temozolamide chemotherapy. ERC-1671 is an experimental treatment strategy that uses the patient's own immune system to attack the tumor cells. The authors report preliminary data on the first human administration of ERC-1671 vaccination under a single-patient, compassionate-use protocol. The patient survived for ten months after the vaccine administration without any other adjuvant therapy and died of complications related to his previous chemotherapies.
Databáze: MEDLINE