| Autor: |
Khaliullin TO; Kazan State Medical University, Kazan, Russia., Shvedova AA, Kisin ER, Zalyalov RR, Fatkhutdinova LM |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2015 Mar; Vol. 158 (5), pp. 684-7. Date of Electronic Publication: 2015 Mar 17. |
| DOI: |
10.1007/s10517-015-2835-7 |
| Abstrakt: |
Local inflammatory response in the lungs and fi brogenic potential of multi-walled carbon nanotubes were studied in an acute aspiration experiment in mice. The doses were chosen based on the concentration of nanotubes in the air at a workplace of the company-producer. ELISA, fl ow cytometry, enhanced darkfield microscopy, and histological examination showed that multi-walled carbon nanotubes induced local inflammation, oxidative stress, and connective tissue growth (fibrosis). Serum levels of TGF-β1 and osteopontin proteins can serve as potential exposure biomarkers. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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