| Autor: |
Ogden DA; Department of Pharmacy, Heriot-Watt University, Edinburgh, UK., McKechnie AA, Bolton DA, Rankin RB, Dobbins SE, Clements JA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 1989; Vol. 7 (11), pp. 1273-80. |
| DOI: |
10.1016/0731-7085(89)80131-1 |
| Abstrakt: |
A method is described for the determination of pipothiazine in human plasma, based on reversed-phase HPLC. The method has been applied in a pharmacokinetic study of pipothiazine in six psychiatric patients receiving repeated depot intramuscular injections for six months. A number of compounds likely to be taken concurrently by patients were tested for potential to interfere with the assay. There was no evidence of "dose-dumping" in the period following injection. Comparison of the pharmacokinetic profiles after the first and sixth injections showed no evidence of drug accumulation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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