Plasma osteoprotegerin concentrations in type 1 diabetic patients with albuminuria.

Autor: Elsamahy MH; Division of Pediatric Diabetes, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Egypt., Elhenawy YI; Division of Pediatric Diabetes, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Egypt. Electronic address: dr_yasmi@yahoo.com., Nawar MM; Division of Pediatric Diabetes, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Egypt.
Jazyk: angličtina
Zdroj: Journal of diabetes and its complications [J Diabetes Complications] 2015 May-Jun; Vol. 29 (4), pp. 563-7. Date of Electronic Publication: 2015 Feb 20.
DOI: 10.1016/j.jdiacomp.2015.02.008
Abstrakt: Background: Osteoprotegerin (OPG) is a recently identified inhibitor of bone resorption. Recent studies indicate that OPG is also associated with endothelial dysfunction in diabetes.
Aim: To investigate the relationship between plasma OPG levels and urinary albumin excretion (UAE) in type 1 diabetes.
Methods: A total of 80 type 1 diabetic subjects and 40 control subjects were enrolled. Diabetic subjects were divided into a normoalbuminuric group and a microalbuminuric group according to urinary albumin excretion rate (UAER). Plasma OPG level was measured by enzyme-linked immunoassay.
Results: The plasma OPG levels were significantly elevated in patients with microalbuminuria (176.39±25.05pg/ml) compared with patients with normoalbuminuria (154.73±16.66pg/ml) and control subjects (44.76±8.7pg/ml). The plasma OPG level had a positive correlation with patients' age, duration of disease, HbA1C and UAER.
Conclusions: Plasma OPG levels are significantly associated with UAE in patients with type 1 diabetes. These findings may support the concept that elevated plasma OPG may be associated with diabetic angiopathy.
(Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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