A comparison of the pathological, clinical and radiographical, features of cryptogenic organising pneumonia, acute fibrinous and organising pneumonia and granulomatous organising pneumonia.

Autor:	Feinstein MB; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA., DeSouza SA; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA., Moreira AL; Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA., Stover DE; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA., Heelan RT; Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA., Iyriboz TA; Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA., Taur Y; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA., Travis WD; Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Jazyk:	angličtina
Zdroj:	Journal of clinical pathology [J Clin Pathol] 2015 Jun; Vol. 68 (6), pp. 441-7. Date of Electronic Publication: 2015 Mar 05.
DOI:	10.1136/jclinpath-2014-202626
Abstrakt:	Aims: Cryptogenic organising pneumonia (COP) and acute fibrinous and organising pneumonia (AFOP) are recognised patterns of organising pneumonia (OP), a condition that resembles pneumonia but is not caused by infection. We have recognised granulomatous organising pneumonia (GOP) to be a similar histopathological entity where non-necrotising granulomata are intimately associated with the organising connective tissue. To what degree COP, AFOP and GOP represent distinct clinical and pathological disorders is unknown. This cross-sectional study sought to compare the pathological, clinical, and radiographical features of these OP patterns. Methods: Surgical lung biopsy specimens were reviewed for consecutive patients referred with OP to a metropolitan cancer centre. Clinical information and CT images were acquired from the hospital electronic medical record to determine the clinical and CT characteristics of each OP pattern. Results: Sixty-one patients (35 men, 26 women), mean age 61.5 years (range 8-85 years), were available for analysis. Of these, 43 patients (70%) had at least one prior cancer; 27 (44%) had received chemotherapy and 18 (30%) had received radiation. Approximately, half (32 patients) had respiratory symptoms, most commonly cough, dyspnoea and/or wheezing. While symptoms and mortality rates were not different among OP groups, AFOP patients more commonly had fever (p=0.04). GOP patients less commonly had received chemotherapy (p=0.03) and were more likely to present as masses/nodules (p=0.04). Conclusions: AFOP and GOP, a newly described OP form, possess clinical and pathological findings that set it apart from a COP, suggesting an emerging spectrum of OP. (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)
Databáze:	MEDLINE
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