Action of rimantadine on the structure of influenza A virus haemagglutinin.

Autor: Mikheeva AV; Moscow Research Institute of Viral Preparations, U.S.S.R., Melnikov AYa, Anisimova E
Jazyk: angličtina
Zdroj: Acta virologica [Acta Virol] 1989 Mar; Vol. 33 (2), pp. 131-6.
Abstrakt: Rimantadine prevents the conformational changes of influenza virus haemagglutinin (HA) caused by acid pH and the acquisition of sensitivity to trypsin, protects the haemolytic activity from inactivation and prevents the morphological changes of HA spikes on the virus surface.
Databáze: MEDLINE