| Autor: |
Ocampo-Garza J; Department of Dermatology, University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Mexico., Herz-Ruelas ME; Department of Dermatology, University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Mexico., González-Lopez EE; Department of Hematology, University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Mexico., Mendoza-Oviedo EE; Department of Pathology, University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Mexico., Garza-Chapa JI; Department of Dermatology, University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Mexico., Ocampo-Garza SS; Department of Dermatology, University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Mexico., Vázquez-Herrera NE; Department of Dermatology, University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Mexico., Miranda-Maldonado I; Department of Pathology, University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Mexico., Ocampo-Candiani J; Department of Dermatology, University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Mexico. |
| Abstrakt: |
Angioimmunoblastic T-cell lymphoma (AITL) accounts for 15-20% of all peripheral T-cell lymphomas. It is a rare subtype of CD4 T-cell peripheral lymphoma that affects aged individuals, causing B symptoms, generalized lymphadenopathy and hepatosplenomegaly. Its pathogenesis is still unclear, but in some cases it has been associated with infection, allergic reaction or drug exposure. The majority of patients are diagnosed in an advanced stage and anthracycline based regimen is considered the first-line therapy. Skin involvement is not well characterized, occurring in up to 50% of patients and presenting as nonspecific rash, macules, papules, petechiae, purpura, nodules and urticaria. We present the illustrative case of a 55-year-old woman with an AITL who presented prominent skin findings, arthritis, lymphadenopathy and hypereosinophilia. Skin biopsy reported a T-cell lymphoma and the diagnosis of AITL was confirmed by an axillary lymph node biopsy, which was also positive for Epstein-Barr virus. Chemotherapy with CHOP-21 and thalidomide was given, accomplishing complete remission after six cycles. |
