| Autor: |
Stucke EM; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center †Department of Pediatrics, University of Cincinnati College of Medicine ‡Division of Pathology and Laboratory Medicine §Division of Human Genetics ||Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Clarridge KE, Collins MH, Henderson CJ, Martin LJ, Rothenberg ME |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2015 Jul; Vol. 61 (1), pp. 65-8. |
| DOI: |
10.1097/MPG.0000000000000740 |
| Abstrakt: |
Eosinophilic esophagitis (EoE) requires a peak count of 15 eosinophils per high-power field (hpf). Herein, the peak eosinophil count specified by a pathologist was compared with the second review of a research assistant. Of 477 biopsies, 106 had a peak count between 1 and 14 eosinophils/hpf cited in the pathology report, and 23/106 (22%) had ≥15 eosinophils/hpf on second review. The pathology report detected potential EoE with 99% specificity, but 80% sensitivity. As such, an additional review of esophageal biopsies yields higher eosinophil counts in ∼5% of cases. We propose that biopsies with a count between 1 and 14 eosinophils/hpf require further investigation because ∼22% may yield a potential EoE diagnosis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text