Parathyroid adenoma in a young female presenting as recurrent acute pancreatitis with a brown tumour of the mandible-A case study.

Autor:	Kunte AR; General Surgical residency, B. J. Medical College and Sassoon General Hospitals, Pune, India. Electronic address: a.kunte13@gmail.com., Dube VS; B. J. Medical College and Sassoon General Hospitals, Pune, India., Balwantkar SS; B. J. Medical College and Sassoon General Hospitals, Pune, India., Kulkarni KK; B. J. Medical College and Sassoon General Hospitals, Pune, India.
Jazyk:	angličtina
Zdroj:	International journal of surgery case reports [Int J Surg Case Rep] 2015; Vol. 7C, pp. 10-5. Date of Electronic Publication: 2014 Nov 27.
DOI:	10.1016/j.ijscr.2014.11.048
Abstrakt:	Introduction: Primary hyperparathyroidism is usually seen in females above the age of 50 years, with a prevalence of 21/1000,(1) whereas the incidence in patients aged 12-28 years is less than 5%.(2) A solitary adenoma is responsible for 80% of cases of primary hyperparathyroidism.(3) Primary hyperparathyroidism is most commonly asymptomatic.(4) The incidence of acute pancreatitis associated with hyperparathyroidism is less than 10%.(5,6) The incidence of hyperparathyroidism associated with a Brown tumour is less than 5%.(7) PRESENTATION OF CASE: A 19 year old female patient presented with recurrent acute pancreatitis and swelling over the mandible. Complete investigative workup revealed a solitary parathyroid adenoma causing hyperparathyroidism. Surgical exploration with excision of the parathyroid adenoma was performed, following which the patient recovered uneventfully. Discussion: The patient was initially managed as a case of acute pancreatitis, and although not suspected initially, a high index of suspicion for hyperparathyroidism developed after a biopsy of the mandibular swelling showed the presence of osteoclastic giant cells indicating the possibility of a Brown tumour. Further investigations then revealed the presence of a solitary parathyroid adenoma with coexistent hyperparathyroidism which was then managed surgically. Conclusion: The young age of the patient, and her presentation with acute pancreatitis and a Brown tumour of the mandible make this an extremely rare presentation of parathyroid adenoma. (Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu