| Autor: |
Lörincz AT; Molecular Diagnostics Research, Life Technologies, Inc., Gaithersburg, Maryland 20877., Quinn AP, Goldsborough MD, McAllister P, Temple GF |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of general virology [J Gen Virol] 1989 Nov; Vol. 70 ( Pt 11), pp. 3099-104. |
| DOI: |
10.1099/0022-1317-70-11-3099 |
| Abstrakt: |
A new human papillomavirus type (HPV-56) was identified by low stringency Southern blot analysis with an HPV-31 DNA probe, in a cervical intraepithelial neoplasm (CIN). The DNA of this virus was molecularly cloned and shown to be a new HPV type based on the absence of cross-reactivity to HPV types 1 to 55 under high-stringency hybridization conditions. At low stringency, HPV-56 was most related to HPV types 30 and 45. The deduced organization of the open reading frames of HPV-56, from hybridization and partial nucleotide sequence analyses, reveals a typical HPV genome. HPV-56 was detected in two of 464 normal cervical tissues, in five of 227 cervical condylomas and CIN, and in two of 84 invasive cancers of the cervix. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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