Prevalence of alpha-1 antitrypsin high-risk variants in Mexican mestizo population and their association with lung function values.

Autor: Pérez-Rubio G; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan, México DF, México; Universidad Nacional Autónoma de México, Coyoacán, México DF, México., Jiménez-Valverde LO; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan, México DF, México., Ramírez-Venegas A; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan, México DF, México., Camarena Á; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan, México DF, México., Sansores RH; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan, México DF, México., Flores-Trujillo F; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan, México DF, México., Reséndiz-Hernández JM; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan, México DF, México; Universidad Nacional Autónoma de México, Coyoacán, México DF, México., Falfán-Valencia R; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan, México DF, México. Electronic address: rfalfanv@iner.gob.mx.
Jazyk: English; Spanish; Castilian
Zdroj: Archivos de bronconeumologia [Arch Bronconeumol] 2015 Feb; Vol. 51 (2), pp. 80-85. Date of Electronic Publication: 2014 Nov 07.
DOI: 10.1016/j.arbres.2014.09.010
Abstrakt: Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by restricted airflow. The best-documented genetic factor is alpha-1 antitrypsin (AAT). AAT is encoded by the SERPINA1 gene. The PiZ (rs28929474) and PiS (rs17580) variants are believed to cause severe AAT deficiency and are linked to a high risk of developing COPD. This study sought to identify whether genetic polymorphisms rs28929474 and rs17580 are associated with COPD susceptibility and lung function values in a Mexican mestizo population.
Methods: In this study, 558 smokers were included, of whom 279 had COPD and 279 did not (smokers without COPD - SWC). The PiS and PiZ variants were genotyped by allelic discrimination. Independent populations and lung function values were compared using the Kruskal-Wallis test. A bivariate logistic regression analysis was also conducted.
Results: Stage I and iv COPD patients showed significant differences in the frequencies of both heterozygous genotypes compared to SWC. For PiS, individuals with the heterozygous genotype AT demonstrated a decreased FEV1/FVC ratio compared to subjects with the homozygous genotype AA (P=0.037). A significant association was found between the FEV1/FVC ratio and genotype AA for PiS (OR=0.982, β coefficient=-0.019, 95% CI=0.966-0.997).
Conclusions: COPD-causing AAT deficiency risk alleles exist at a very low frequency among Mexican mestizo population. Although they are not directly linked in our study population with disease susceptibility, these risk alleles are associated with poorer lung function measurements. It is important to characterize how often these genetic risk variants occur in other Latin American populations.
(Copyright © 2014 SEPAR. Published by Elsevier Espana. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: