Antidepressant activity of methanolic extract of amaranthus spinosus.
| Autor: | Ashok Kumar BS; Department of Pharmacognosy, Sri K.V. College of Pharmacy, Chickballapur, Karnataka,India., Lakshman K; Department of Pharmacognosy, PES College of Pharamcy, Bangalore, Karnataka, India., Velmurugan C; Department of Pharmacology, Sree Krishna Chaitanya College of Pharmacy, Madanapalle, Andhrapradesh, India., Sridhar SM; Department of Pharmacology, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India., Gopisetty S; Department of Pharmacognosy, Sri K.V. College of Pharmacy, Chickballapur, Karnataka,India. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Basic and clinical neuroscience [Basic Clin Neurosci] 2014 Winter; Vol. 5 (1), pp. 11-7. |
| Abstrakt: | Introduction: Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. Amaranthus spinosus was investigation for antidepressant activity. Methods: Antidepressant activity of methanolic extract of Amaranthus spinosus (MEAS) was investigated by using Forced swimming test (FST) and Tail suspension test (TST) models. Escitalopram and Imipramine were used as reference standards. Results: It has been observed from our study that both the MEAS at higher concentration showed significant (p<0.01) reduction in immobility in tail suspension and forced swim model of depression comparable to Escitalopram and Imipramine. Discussion: However further study is needed to understand mechanism of action and to identify active component responsible for antidepressant like activity. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|