| Autor: |
Arutyunyan TV; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia., Korystova AF, Kublik LN, Levitman MKh, Shaposhnikova VV, Appazov NO, Narmanova RA, Ibadullayeva SZh, Korystov YN |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2014 Dec; Vol. 158 (2), pp. 222-4. |
| DOI: |
10.1007/s10517-014-2727-2 |
| Abstrakt: |
We studied the effect of camel thorn extract on activity of angiotensin-converting enzyme in rat aorta increased in animals during aging or treatment with NO-synthase inhibitor. Intake of camel thorn extract with drinking water reduced activity of angiotensin-converting enzyme; the effect increased with increasing the dose of the extract. Angiotensin-converting enzyme activity in older rats and animals treated with NO-synthase inhibitor decreased to the values observed in young control rats at extract concentration of 0.2%. Comparison of the effects of camel thorn extract with those of flavonoid taxifolin showed that the extract was not inferior to taxifolin in preventing the early stages of aortic atherosclerosis caused by increased activity of angiotensin-converting enzyme. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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