Radiosynovectomy of the elbow joint synovitis in rheumatoid arthritis treated with Lutetium - 177 labeled hydroxylapatite (Lu-177 HA) particulates; first case report and image of Lu -177 HA in the elbow joint.

Autor: Kamaleshwaran KK; Department of Nuclear Medicine and PET/CT, Kovai Medical Centre and Hospital Limited, Coimbatore, Tamil Nadu, India., Rajamani V; Department of Rheumatology, Kovai Medical Centre and Hospital Limited, Coimbatore, Tamil Nadu, India., Thirumalaisamy SG; Department of Orthopedics, Kovai Medical Centre and Hospital Limited, Coimbatore, Tamil Nadu, India., Chakraborty S; Isotope Applications and Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India., Kalarikal R; Department of Nuclear Medicine and PET/CT, Kovai Medical Centre and Hospital Limited, Coimbatore, Tamil Nadu, India., Mohanan V; Department of Nuclear Medicine and PET/CT, Kovai Medical Centre and Hospital Limited, Coimbatore, Tamil Nadu, India., Shinto AS; Department of Nuclear Medicine and PET/CT, Kovai Medical Centre and Hospital Limited, Coimbatore, Tamil Nadu, India.
Jazyk: angličtina
Zdroj: Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India [Indian J Nucl Med] 2014 Oct; Vol. 29 (4), pp. 270-2.
DOI: 10.4103/0972-3919.142644
Abstrakt: Rheumatoid arthritis is a chronic disease that is mainly characterized by asymmetric erosive synovitis, particularly affecting the peripheral joints. Radiation synovectomy or radiosynovectomy, also known as radiosynoviorthesis was first described in 1950's as a adjuvant treatment for rheumatoid arthritis. Radiosynovectomy is based on the irradiation of the joint synovium by the intra-articular administration of various β-emitting radiopharmaceuticals. Lu-177 has presence of gamma photons of imagable energy with low abundance which provides the additional benefit of carrying out simultaneous scintigraphy. We describe the first case report of use of Lu-177 hydroxylapatite particulates in a 35-year-old female patient who was presented with elbow joint synovitis due to rheumatoid arthritis.
Databáze: MEDLINE
Externí odkaz: