The efficacy of antioxidant therapy against oxidative stress and androgen rise in ethylene glycol induced nephrolithiasis in Wistar rats.

Autor:	Naghii MR; Sport Physiology Research Center and Department of Nutrition, Health School, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Islamic Republic of Iran naghiimr@yahoo.com., Jafari M; Department of Nutrition, Health School, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Islamic Republic of Iran., Mofid M; Department of Anatomy, Faculty of Medicine, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Islamic Republic of Iran., Eskandari E; Department of Nutrition, Health School, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Islamic Republic of Iran., Hedayati M; Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran., Khalagie K; Department of Epidemiology and Statistics, Health School, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Human & experimental toxicology [Hum Exp Toxicol] 2015 Jul; Vol. 34 (7), pp. 744-54. Date of Electronic Publication: 2014 Nov 11.
DOI:	10.1177/0960327114558889
Abstrakt:	Administration of natural antioxidants has been used to protect against nephrolithiasis. Urolithiasis was induced by ethylene glycol (EG) in Wistar rats. For 4 weeks, group 1 (control) was fed with a standard commercial diet. Group 2 received the same diet with 0.75% of EG. Group 3 received EG plus the diet and water added with antioxidant nutrients and lime juice as the dietary source of citrate (EG + AX). Group 4 same as group 3 with no EG in water. For 8 weeks, group 5 was fed the standard diet with EG in water for the first 28 days, followed by no EG. Group 6 received the diet with EG for the first 28 days, followed by discontinuation of EG and addition of antioxidant nutrients. Group 7 were provided the diet with antioxidant nutrients for 8 weeks. Group 8 received the diet with antioxidant nutrients for 4 weeks, followed by antioxidant nutrients with EG for the next 4 weeks. Blood samples were collected and kidneys were removed. The size and the mean number of crystal deposits in EG-treated groups was significantly higher than the EG-treated groups, added with antioxidant nutrients and lime juice. After 4 weeks, the mean concentration of malondialdehyde in group 2 was higher than the group 3, and significantly lower in group 4; and in groups 7 after 8 weeks, as well. After 8 weeks, supplementation developed less mean number of deposits in group 6 as compared to group 5; and in group 8, the crystal deposits was substantially less than either group 2 or group 5 (EG-treated rats). Elevated concentration of androgens (as promoters of the formation of renal calculi) as a result of EG consumption decreased following antioxidant supplementations. Results showed a beneficial effect of antioxidant and provided superior renal protection on treating and preventing stone deposition in the rat kidney. (© The Author(s) 2014.)
Databáze:	MEDLINE
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