Natural history of polyomaviruses in men: the HPV infection in men (HIM) study.

Autor:	Hampras SS; Department of Cancer Epidemiology., Giuliano AR; Department of Cancer Epidemiology., Lin HY; Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida., Fisher KJ; Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida., Abrahamsen ME; Department of Cancer Epidemiology., McKay-Chopin S; Infections and Cancer Biology Group, International Agency for Research on Cancer-World Health Organization, Lyon, France., Gheit T; Infections and Cancer Biology Group, International Agency for Research on Cancer-World Health Organization, Lyon, France., Tommasino M; Infections and Cancer Biology Group, International Agency for Research on Cancer-World Health Organization, Lyon, France., Rollison DE; Department of Cancer Epidemiology.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2015 May 01; Vol. 211 (9), pp. 1437-46. Date of Electronic Publication: 2014 Nov 11.
DOI:	10.1093/infdis/jiu626
Abstrakt:	Background: Several new polyomaviruses have been discovered in the last decade, including Merkel cell polyomavirus (MCPyV). Little is known about the natural history of the more recently discovered polyomaviruses. We estimated the incidence, prevalence, and persistence of 9 polyomaviruses (MCPyV, BK polyomavirus, KI polyomavirus, JC polyomavirus, WU polyomavirus, Human polyomavirus 6 [HPyV6], HPyV7, HPyV9, and Trichodysplasia spinulosa-associated polyomavirus) and examined factors associated with MCPyV infection in a prospective cohort of 209 men initially enrolled in the HPV Infection in Men (HIM) study. Methods: Participants enrolled at the US site of the HIM study were recruited into a substudy of cutaneous viral infections and followed for a median of 12.6 months. Eyebrow hair and normal skin swab specimens were obtained at each study visit, and the viral DNA load was measured using multiplex polymerase chain reaction. Results: MCPyV infection showed the highest prevalence (65.1% of normal skin swab specimens and 30.6% of eyebrow hair specimens), incidence (81.7 cases per 1000 person-months among normal skin swab specimens, and 24.1 cases per 1000 person-months among eyebrow hair specimens), and persistence (85.8% of normal skin swab specimens and 58.9% of eyebrow hair specimens) among all polyomaviruses examined. Age of >44 years (odds ratio [OR], 2.11; 95% confidence interval [CI], 1.03-4.33) and Hispanic race (OR, 2.64; 95% CI, 1.01-6.88) were associated with an increased prevalence of MCPyV infection in eyebrow hair and normal skin swab specimens, respectively. Conclusion: MCPyV infection is highly prevalent in adults, with age and race being predisposing factors. (© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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