Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder.

Autor: Grosse L; Department of Psychiatry and Psychotherapy, University of Münster, Germany. Electronic address: laura.grosse@ukmuenster.de., Carvalho LA; Department of Epidemiology and Public Health, University College London, United Kingdom., Wijkhuijs AJ; Department of Immunology, Erasmus MC, Rotterdam, The Netherlands., Bellingrath S; Department of Psychology, University of Duisburg-Essen, Germany., Ruland T; Department of Psychiatry and Psychotherapy, University of Münster, Germany., Ambrée O; Department of Psychiatry and Psychotherapy, University of Münster, Germany., Alferink J; Department of Psychiatry and Psychotherapy, University of Münster, Germany; Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Germany., Ehring T; Department of Psychology, University of Münster, Germany., Drexhage HA; Department of Immunology, Erasmus MC, Rotterdam, The Netherlands., Arolt V; Department of Psychiatry and Psychotherapy, University of Münster, Germany.
Jazyk: angličtina
Zdroj: Brain, behavior, and immunity [Brain Behav Immun] 2015 Feb; Vol. 44, pp. 48-56. Date of Electronic Publication: 2014 Aug 20.
DOI: 10.1016/j.bbi.2014.08.004
Abstrakt: Increased inflammatory activation might only be present in a subgroup of depressed individuals in which immune processes are especially relevant to disease development. We aimed to analyze demographic, depression, and trauma characteristics of major depressive disorder (MDD) patients with regard to inflammatory monocyte gene expression. Fifty-six naturalistically treated MDD patients (32 ± 12 years) and 57 healthy controls (HC; 31 ± 11 years) were analyzed by the Inventory of Depressive Symptomatology (IDS) and by the Childhood Trauma Questionnaire (CTQ). We determined the expression of 38 inflammatory and immune activation genes including the glucocorticoid receptor (GR)α and GRβ genes in purified CD14(+) monocytes using quantitative-polymerase chain reaction (RT-qPCR). Monocyte gene expression was age-dependent, particularly in MDD patients. Increased monocyte gene expression and decreased GRα/β ratio were only present in MDD patients aged ⩾ 28 years. Post hoc analyses of monocyte immune activation in patients <28 years showed two subgroups: a subgroup with a severe course of depression (recurrent type, onset <15 years) - additionally characterized by panic/arousal symptoms and childhood trauma - that had a monocyte gene expression similar to HC, and a second subgroup with a milder course of the disorder (73% first episode depression, onset ⩾15 years) - additionally characterized by the absence of panic symptoms - that exhibited a strongly reduced inflammatory monocyte activation compared to HC. In conclusion, monocyte immune activation was not uniformly raised in MDD patients but was increased only in patients of 28 years and older.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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