Thermally-Induced Substrate Release Via Intramolecular Cyclizations of Amino Esters and Amino Carbonates.

Autor: Knipp RJ; Department of Chemistry, University of Louisville, Louisville, KY 40292, USA., Estrada R; Department of Bioengineering, University of Louisville, Louisville, KY 40292, USA., Sethu P; Department of Bioengineering, University of Louisville, Louisville, KY 40292, USA., Nantz MH; Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.
Jazyk: angličtina
Zdroj: Tetrahedron [Tetrahedron] 2014 May 01; Vol. 70 (21), pp. 3422-3429.
DOI: 10.1016/j.tet.2014.03.092
Abstrakt: The relative cleavage of an alcohol from a panel of amino esters and amino carbonates via intramolecular cyclization was examined as a mechanism for substrate release. Thermal stability at 37 °C was observed only for the 7-membered ring progenitors. Applicability of the approach was illustrated by δ-lactam formation within a poly(dimethylsiloxane) microchannel for release of a captured fluorescent probe.
Databáze: MEDLINE
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