Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans.

Autor:	Chondronikola M; Metabolism Unit, Shriners Hospital for Children, Galveston, TX Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX Department of Nutrition and Metabolism, Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece., Volpi E; Department of Nutrition and Metabolism, Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX., Børsheim E; Metabolism Unit, Shriners Hospital for Children, Galveston, TX Department of Surgery, University of Texas Medical Branch, Galveston, TX., Porter C; Metabolism Unit, Shriners Hospital for Children, Galveston, TX Department of Surgery, University of Texas Medical Branch, Galveston, TX., Annamalai P; Department of Interventional Radiology, University of Texas Medical Branch, Galveston, TX., Enerbäck S; Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Lidell ME; Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Saraf MK; Metabolism Unit, Shriners Hospital for Children, Galveston, TX Department of Surgery, University of Texas Medical Branch, Galveston, TX., Labbe SM; Quebec Heart and Lung Research Institute Centre, Quebec City, Quebec, Canada., Hurren NM; Metabolism Unit, Shriners Hospital for Children, Galveston, TX Department of Surgery, University of Texas Medical Branch, Galveston, TX., Yfanti C; Metabolism Unit, Shriners Hospital for Children, Galveston, TX Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX., Chao T; Metabolism Unit, Shriners Hospital for Children, Galveston, TX Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX Department of Nutrition and Metabolism, Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX., Andersen CR; Metabolism Unit, Shriners Hospital for Children, Galveston, TX Department of Surgery, University of Texas Medical Branch, Galveston, TX., Cesani F; Department of Nuclear Medicine, University of Texas Medical Branch, Galveston, TX., Hawkins H; Department of Pathology, University of Texas Medical Branch, Galveston, TX Department of Pathology, Shriners Hospital for Children, Galveston, TX., Sidossis LS; Metabolism Unit, Shriners Hospital for Children, Galveston, TX Department of Nutrition and Metabolism, Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX lasidoss@utmb.edu.
Jazyk:	angličtina
Zdroj:	Diabetes [Diabetes] 2014 Dec; Vol. 63 (12), pp. 4089-99. Date of Electronic Publication: 2014 Jul 23.
DOI:	10.2337/db14-0746
Abstrakt:	Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic tissue owing to its ability to dissipate energy as heat. Despite a plethora of data concerning the role of BAT in glucose metabolism in rodents, the role of BAT (if any) in glucose metabolism in humans remains unclear. To investigate whether BAT activation alters whole-body glucose homeostasis and insulin sensitivity in humans, we studied seven BAT-positive (BAT(+)) men and five BAT-negative (BAT(-)) men under thermoneutral conditions and after prolonged (5-8 h) cold exposure (CE). The two groups were similar in age, BMI, and adiposity. CE significantly increased resting energy expenditure, whole-body glucose disposal, plasma glucose oxidation, and insulin sensitivity in the BAT(+) group only. These results demonstrate a physiologically significant role of BAT in whole-body energy expenditure, glucose homeostasis, and insulin sensitivity in humans, and support the notion that BAT may function as an antidiabetic tissue in humans. (© 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.)
Databáze:	MEDLINE
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