Radiation-induced cognitive impairment and altered diffusion tensor imaging in a juvenile rat model of cranial radiotherapy.

Autor: Peiffer AM; Department of Radiation Oncology, Wake Forest School of Medicine , Winston-Salem, NC., Creer RM, Linville C, Olson J, Kulkarni P, Brown JA, Riddle DR, Robbins ME, Brunso-Bechtold JE
Jazyk: angličtina
Zdroj: International journal of radiation biology [Int J Radiat Biol] 2014 Sep; Vol. 90 (9), pp. 799-806. Date of Electronic Publication: 2014 Aug 11.
DOI: 10.3109/09553002.2014.938278
Abstrakt: Purpose: To assess the long-term effects of fractionated whole brain irradiation (fWBI) using diffusion tensor imaging (DTI) and behavior in a pediatric rodent model for the clinical presentation of adult pediatric cancer survivors.
Materials and Methods: Five-week-old, male F344xBN rats were randomized to receive 0, 5, or 6.5 Gy fractions biweekly for 3 weeks, resulting in Sham, Irradiated-30 (IR-30) and IR-39 Gy total dose groups. Magnetic Resonance Imaging occurred at 1, 3, 6 and 9 months with behavioral assessment at 10-11 months post-fWBI.
Results: Irradiation reduced brain size (p < 0.001) and body weight (p < 0.001) proportionate to dose. At 1 month post-fWBI and throughout follow-up, diffusion was reduced in IR-30 and IR-39 relative to shams (p < 0.001). IR-30 but not IR-39 rats were impaired relative to Shams on the reversal trial of the Morris Water Maze (p < 0.05), and IR-30 rats preferred a striatum- mediated strategy (p < 0.06).
Conclusions: Hippocampal performance was impaired in IR-30 but not IR-39 animals. While gross size differences exist, white matter integrity is preserved in rats after fWBI at 5 weeks. This significant departure from childhood cancer survivors and single fraction rodent studies where white matter degradation is a prominent feature are discussed.
Databáze: MEDLINE
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