Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the Human Cancer Protein Interaction Network.

Autor: Pulavarti SV; Department of Chemistry, The State University of New York at Buffalo and Northeast Structural Genomics Consortium, Buffalo, NY, 14260, USA., Huang YJ, Pederson K, Acton TB, Xiao R, Everett JK, Prestegard JH, Montelione GT, Szyperski T
Jazyk: angličtina
Zdroj: Journal of structural and functional genomics [J Struct Funct Genomics] 2014 Dec; Vol. 15 (4), pp. 209-14. Date of Electronic Publication: 2014 Jul 03.
DOI: 10.1007/s10969-014-9185-y
Abstrakt: High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human obscurin-like protein 1 were solved. The two domains share 30% sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associated proteins. Mutations of Arg 812 in domain 7 cause the rare 3-M syndrome, and this site is located in a surface area predicted to be involved in protein-protein interactions.
Databáze: MEDLINE
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