Hippocampal representation of related and opposing memories develop within distinct, hierarchically organized neural schemas.

Autor:	McKenzie S; Center for Memory and Brain, Boston University, Boston, MA 02215, USA., Frank AJ; Center for Memory and Brain, Boston University, Boston, MA 02215, USA., Kinsky NR; Center for Memory and Brain, Boston University, Boston, MA 02215, USA., Porter B; Center for Memory and Brain, Boston University, Boston, MA 02215, USA., Rivière PD; Center for Memory and Brain, Boston University, Boston, MA 02215, USA., Eichenbaum H; Center for Memory and Brain, Boston University, Boston, MA 02215, USA. Electronic address: hbe@bu.edu.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2014 Jul 02; Vol. 83 (1), pp. 202-15. Date of Electronic Publication: 2014 Jun 05.
DOI:	10.1016/j.neuron.2014.05.019
Abstrakt:	Recent evidence suggests that the hippocampus may integrate overlapping memories into relational representations, or schemas, that link indirectly related events and support flexible memory expression. Here we explored the nature of hippocampal neural population representations for multiple features of events and the locations and contexts in which they occurred. Hippocampal networks developed hierarchical organizations of associated elements of related but separately acquired memories within a context, and distinct organizations for memories where the contexts differentiated object-reward associations. These findings reveal neural mechanisms for the development and organization of relational representations. (Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu