| Autor: |
Skurikhin EG; Department of Pathophysiology and Regenerative Medicine Research Institute of Pharmacology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russia., Reztsova AM, Ermakova NN, Krupin VA, Pershina OV, Khmelevskaya ES, Artamonov AV, Bekarev AA, Madonov PG, Kinsht DN, Reykhard DV, Goldberg VE, Dygai AM |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2014 May; Vol. 157 (1), pp. 5-9. Date of Electronic Publication: 2014 Jun 08. |
| DOI: |
10.1007/s10517-014-2478-0 |
| Abstrakt: |
Antifibrotic activity of intranasally administered conjugates of pluronics L31 and F68 with hyaluronate-endo-β-N-acetylhexosaminidase was studied in C57Bl/6 mice under conditions of single and repeated bleomycin-induced injury to the alveolar epithelium. Conjugates were prepared using the technique of protein immobilization with ionizing radiation. We demonstrate that in cases of single and repeated injuries to the alveolar epithelium, the conjugates administered during phases of inflammation or deposition of fibrotic masses prevent the development of pulmonary fibrosis. The conjugates demonstrated more pronounced antifibrotic activity than hyaluronate-endo-β-N-acetylhexosaminidase. The conjugate based on hydrophobic pluronic L31 showed higher effectiveness in comparison with the conjugate based on amphiphilic pluronic F68. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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