| Autor: |
Yetisen AK; Department of Chemical Engineering and Biotechnology, University of Cambridge , Tennis Court Road, Cambridge CB2 1QT, United Kingdom., Montelongo Y, da Cruz Vasconcellos F, Martinez-Hurtado JL, Neupane S, Butt H, Qasim MM, Blyth J, Burling K, Carmody JB, Evans M, Wilkinson TD, Kubota LT, Monteiro MJ, Lowe CR |
| Jazyk: |
angličtina |
| Zdroj: |
Nano letters [Nano Lett] 2014 Jun 11; Vol. 14 (6), pp. 3587-93. Date of Electronic Publication: 2014 May 20. |
| DOI: |
10.1021/nl5012504 |
| Abstrakt: |
Developing noninvasive and accurate diagnostics that are easily manufactured, robust, and reusable will provide monitoring of high-risk individuals in any clinical or point-of-care environment. We have developed a clinically relevant optical glucose nanosensor that can be reused at least 400 times without a compromise in accuracy. The use of a single 6 ns laser (λ = 532 nm, 200 mJ) pulse rapidly produced off-axis Bragg diffraction gratings consisting of ordered silver nanoparticles embedded within a phenylboronic acid-functionalized hydrogel. This sensor exhibited reversible large wavelength shifts and diffracted the spectrum of narrow-band light over the wavelength range λpeak ≈ 510-1100 nm. The experimental sensitivity of the sensor permits diagnosis of glucosuria in the urine samples of diabetic patients with an improved performance compared to commercial high-throughput urinalysis devices. The sensor response was achieved within 5 min, reset to baseline in ∼10 s. It is anticipated that this sensing platform will have implications for the development of reusable, equipment-free colorimetric point-of-care diagnostic devices for diabetes screening. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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