Experience-Dependent, Layer-Specific Development of Divergent Thalamocortical Connectivity.

Autor:	Crocker-Buque A; Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK., Brown SM; Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK., Kind PC; Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK., Isaac JT; Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA Current address: Lilly UK, Erl Wood Manor, Windlesham, UK., Daw MI; Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2015 Aug; Vol. 25 (8), pp. 2255-66. Date of Electronic Publication: 2014 Mar 07.
DOI:	10.1093/cercor/bhu031
Abstrakt:	The main input to primary sensory cortex is via thalamocortical (TC) axons that form the greatest number of synapses in layer 4, but also synapse onto neurons in layer 6. The development of the TC input to layer 4 has been widely studied, but less is known about the development of the layer 6 input. Here, we show that, in neonates, the input to layer 6 is as strong as that to layer 4. Throughout the first postnatal week, there is an experience-dependent strengthening specific to layer 4, which correlates with the ability of synapses in layer 4, but not in layer 6, to undergo long-term potentiation (LTP). This strengthening consists of an increase in axon branching and the divergence of connectivity in layer 4 without a change in the strength of individual connections. We propose that experience-driven LTP stabilizes transient TC synapses in layer 4 to increase strength and divergence specifically in layer 4 over layer 6. (© The Author 2014. Published by Oxford University Press.)
Databáze:	MEDLINE
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