SV40 TAg mouse models of cancer.

Autor: Colvin EK; Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: emily.colvin@sydney.edu.au., Weir C; Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: chris.weir@sydney.edu.au., Ikin RJ; Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: rowan.ikin@sydney.edu.au., Hudson AL; Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: Amanda.Hudson@sydney.edu.au.
Jazyk: angličtina
Zdroj: Seminars in cell & developmental biology [Semin Cell Dev Biol] 2014 Mar; Vol. 27, pp. 61-73. Date of Electronic Publication: 2014 Feb 25.
DOI: 10.1016/j.semcdb.2014.02.004
Abstrakt: The discovery of a number of viruses with the ability to induce tumours in animals and transform human cells has vastly impacted cancer research. Much of what is known about tumorigenesis today regarding tumour drivers and tumour suppressors has been discovered through experiments using viruses. The SV40 virus has proven extremely successful in generating transgenic models of many human cancer types and this review provides an overview of these models and seeks to give evidence as to their relevance in this modern era of personalised medicine and technological advancements.
(Copyright © 2014 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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