Extended-spectrum β-lactamase-producing Klebsiella pneumoniae in the neonatal intensive care unit: does vancomycin play a role?

Autor: Somily AM; Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Alsubaie SS; Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia., BinSaeed AA; Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Electronic address: abinsaid@ksu.edu.sa., Torchyan AA; Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Alzamil FA; Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Al-Aska AI; Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Al-Khattaf FS; Department of Infection Control, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Khalifa LA; Department of Infection Control, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Al-Thawadi SI; Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Alaidan AA; Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Al-Ahdal MN; Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Al-Qahtani AA; Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Murray TS; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT.
Jazyk: angličtina
Zdroj: American journal of infection control [Am J Infect Control] 2014 Mar; Vol. 42 (3), pp. 277-82.
DOI: 10.1016/j.ajic.2013.09.028
Abstrakt: Background: Extended-spectrum β-lactamase (ESBL)-producing Klebsiella species cause worldwide problems in neonatal intensive care units (NICUs). This study aimed to determine possible risk factors for infection or colonization with ESBL-producing Klebsiella pneumoniae (ESBLKp) during an outbreak in the NICU.
Methods: A retrospective cohort study was conducted among neonates admitted to the NICU of a teaching hospital in Riyadh, Saudi Arabia, during an outbreak of ESBLKp from April to July 2008. The incidence density ratio was calculated to determine possible predictors of ESBLKp colonization or infection.
Results: During 2,265 person-days of follow-up of 118 neonates, 4 became infected, and 8 were colonized with ESBLKp. Univariate analyzes revealed that, among 14 neonates who were treated with vancomycin, 9 (64.3%) developed infection or colonization with ESBLKp, whereas, among 104 neonates who were not treated with vancomycin, 3 (2.9%) were affected, with an incidence density ratio of 4.22 (95% confidence interval: 1.47-5.15). Parenteral feeding and mechanical ventilation were found to be marginally significant risk factors.
Conclusion: Treatment with vancomycin appears to be a risk factor for infection or colonization with ESBLKp in the NICU setting.
(Copyright © 2014 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.)
Databáze: MEDLINE
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