Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection.
| Autor: | Fecury AA, Almeida MK, Santos KN, Freitas Ada S, Dantas Sde F, Costa CA, Crescente ÂB, Sousa RC, Brito EB, Nassiri R, Lampe E, Martins LC |
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| Jazyk: | angličtina |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2014 Jan-Feb; Vol. 47 (1), pp. 90-2. |
| DOI: | 10.1590/0037-8682-0008-2012 |
| Abstrakt: | Introduction: The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression. Methods: Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation. Results: Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis. Conclusions: HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction. |
| Databáze: | MEDLINE |
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