[Efficacy of the subcutaneous route compared to intravenous hydration in the elderly hospitalised patient: a randomised controlled study].

Autor:	Duems Noriega O; Servicio de Geriatría, Hospital General de Granollers, Granollers, Barcelona, España. Electronic address: oduems@fhag.es., Ariño Blasco S; Servicio de Geriatría, Hospital General de Granollers, Granollers, Barcelona, España.
Jazyk:	Spanish; Castilian
Zdroj:	Revista espanola de geriatria y gerontologia [Rev Esp Geriatr Gerontol] 2014 May-Jun; Vol. 49 (3), pp. 103-7. Date of Electronic Publication: 2014 Jan 29.
DOI:	10.1016/j.regg.2013.12.003
Abstrakt:	Introduction: The subcutaneous (SC) route has recently emerged as a rehydration method with potential advantages in the geriatric population. Nevertheless, little is known about its application during hospitalization. The objective of the present study is to evaluate the subcutaneous non-inferiority efficacy in hydration against the intravenous (IV) route in elderly patients with dehydration. Material and Methods: A prospective, randomized and controlled interventional trial of patients 65 years and older admitted to an Acute Geriatric Unit with mild to moderate dehydration and oral intolerance, evaluating the non-inferiority of subcutaneous fluid therapy versus the intravenous route. The intervention consisted of the administration of up to 1.5 l/day/route for 72 hours subcutaneous vs. intravenous, evaluating the variations in biochemical parameters (urea, creatinine, osmolarity), clinical outcome, and route related complications. Results: Sixty seven patients completed the study (34 SC, age 86.4 ± 8.5 years, 41% women, vs. 33 IV, 84.3 ± 6.6, 54.5% women, with no significant differences). The amount of fluid administered per day by route was 1.320 ml ± 400 SC vs. 1.480 ml ± 340 IV, P = .092. During follow similar reductions were observed between groups without any statistical significance, with mean differences pre-postintervention of urea (49.6 ± 52.3 SC vs. 50.3 ± 52.3 IV, P=.96); creatinine (0.68 ± 0.66 SC vs. 0.60 ± 0.49 IV, P=.58), and osmolarity (15.6 ± 24.4 SC vs. 21.1 ± 31 IV, P=.43). Fewer catheter extraction episodes were observed in the SC group, which also was the group most prone to peri-clysis edema. Conclusions: The efficacy of subcutaneous rehydration in elderly hospitalized patients with mild-moderate dehydration is not inferior to that obtained intravenously, and may even have additional advantages. (Copyright © 2013 SEGG. Published by Elsevier Espana. All rights reserved.)
Databáze:	MEDLINE
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