Markers of epithelial-mesenchymal transition in renal cell carcinoma.

Autor:	Dumanskiy YV; Department of Oncology, Maksim Gorky National Medical University, Donetsk 83092, Ukraine., Kudriashov AG; Department of Oncology, Maksim Gorky National Medical University, Donetsk 83092, Ukraine., Vasilenko IV; Department of Pathology, Maksim Gorky National Medical University, Donetsk 83003, Ukraine., Kondratyuk RB; Department of Pathology, Maksim Gorky National Medical University, Donetsk 83003, Ukraine., Gulkov YK; Department of Pathology, Maksim Gorky National Medical University, Donetsk 83003, Ukraine., Cyrillichystiakov RS; Donetsk Regional Anticancer Center, Donetsk 83092, Ukraine.
Jazyk:	angličtina
Zdroj:	Experimental oncology [Exp Oncol] 2013 Dec; Vol. 35 (4), pp. 325-7.
Abstrakt:	Aim: To study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. Methods: The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3-6 months) and a long-term survival group (17-24 months). EMT markers expression was assessed by immunohistochemical methods. Results: It was determined that the rate of spindle-cell EMT was 96.4% in a short-term survival group and 42.1% in a long-term survival group. High rate Furhman's nuclear atypia, i.e. degree 3-4 occurred in 100% of cases in a short-term survival group versus 68.4% in a long-term survival group. Conclusion: The rate of spindle-cell EMT in RCC may serve a more sensible prognostic factor than the degree of Furhman's nuclear atypia.
Databáze:	MEDLINE
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