Drug allergy in tertiary care in Turkey: results of a national survey. The ADAPT study: adult drug allergy perception in Turkey.

Autor:	Çelik GE; Ankara University School of Medicine, Cebeci Research Hospital, Department of Chest Diseases, Division of Immunology and Allergy, Turkey. Electronic address: gulfemcelik@gmail.com., Karakaya G; Hacettepe University School of Medicine, Department of Chest Disease, Adult Allergy Unit, Turkey., Öztürk AB; Hacettepe University School of Medicine, Department of Chest Disease, Adult Allergy Unit, Turkey., Gelincik A; Istanbul University School of Medicine, Department of Internal Medicine, Division of Allergy, Turkey., Abadoğlu O; Cumhuriyet University School of Medicine, Department of Chest Diseases, Division of Immunology and Allergic Diseases, Turkey., Sin A; Ege University School of Medicine, Department of Internal Medicine, Division of Allergy and Clinical Immunology, Turkey., Damadoğlu E; Hacettepe University School of Medicine, Department of Chest Disease, Adult Allergy Unit, Turkey., Yılmaz İ; Ankara University School of Medicine, Cebeci Research Hospital, Department of Chest Diseases, Division of Immunology and Allergy, Turkey., Demirtürk M; Istanbul University School of Medicine, Department of Internal Medicine, Division of Allergy, Turkey., Dursun B; Ataturk Chest Diseases and Thoracic Surgery, Training and Research Hospital, Turkey., Özdemir SK; Ankara University School of Medicine, Cebeci Research Hospital, Department of Chest Diseases, Division of Immunology and Allergy, Turkey., Çelikel S; Gaziosmanpasa University, School of Medicine, Department of Pulmonary Diseases, Turkey., Değirmenci P; Celal Bayar University School of Medicine, Department of Internal medicine, Division of Immunology and Allergy, Turkey., Bozkurt B; Fatih University School of Medicine, Department of Chest Diseases, Division of Immunology and Allergy, Turkey., Göksel Ö; Izmir Ataturk Training and Research Hospital, Turkey., Erkekol FÖ; Ataturk Chest Diseases and Thoracic Surgery, Training and Research Hospital, Turkey., Aydın Ö; Ankara University School of Medicine, Cebeci Research Hospital, Department of Chest Diseases, Division of Immunology and Allergy, Turkey., Kavut AB; Kırıkkale University School of Medicine, Department of Chest Diseases, Division of Immunology and Allergic Diseases, Turkey., Kırmaz C; Celal Bayar University School of Medicine, Department of Internal medicine, Division of Immunology and Allergy, Turkey., Kalpaklıoğlu F; Kırıkkale University School of Medicine, Department of Chest Diseases, Division of Immunology and Allergic Diseases, Turkey., Büyüköztürk S; Istanbul University School of Medicine, Department of Internal Medicine, Division of Allergy, Turkey., Kalyoncu F; Hacettepe University School of Medicine, Department of Chest Disease, Adult Allergy Unit, Turkey.
Jazyk:	angličtina
Zdroj:	Allergologia et immunopathologia [Allergol Immunopathol (Madr)] 2014 Nov-Dec; Vol. 42 (6), pp. 573-9. Date of Electronic Publication: 2013 Oct 23.
DOI:	10.1016/j.aller.2013.07.007
Abstrakt:	Background: No data are available on the incidence of drug hypersensitivity (DH) reactions in outpatient settings of tertiary allergy/immunology clinics. Our aims were to document the frequency of outpatient hospital admissions due to DH reactions to allergy/immunology clinics in adults and the management of these reactions in real life. We also investigated whether drug allergy affected social and medical behaviours of the patients. Methods: This multi-centre study was performed for one year with the participation of 11 out of 16 tertiary allergy/clinical immunology clinics in Turkey. The study group consisted of the patients with DH reactions. Results of a questionnaire including drug reactions and management were recorded. Results: Among 54,863 patients, 1000 patients with DH were enrolled with a median of 2.1% of all admissions. In real life conditions, the majority of approaches were performed for finding safe alternatives (65.5%; 1102 out of 1683) with 11.7% positivity. Diagnostic procedures were positive in 27% (154/581) of the patients. The majority of the patients had higher VAS scores for anxiety. A total of 250 subjects (25%) reported that they delayed some medical procedures because of DH. Conclusion: Our results documented the frequency of admissions due to DH reactions to allergy/clinical immunology clinics for the first time. Although physicians mostly preferred to perform drug tests in order to find safe alternatives, considering the fact that DH was confirmed in 27% of the patients, use of diagnostic tests should be encouraged, if no contraindication exists in order to avoid mislabelling patients as DH. (Copyright © 2013 SEICAP. Published by Elsevier Espana. All rights reserved.)
Databáze:	MEDLINE
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